RESUMO
The potassium hydrocarbonate and potassium chloride toxicity was compared in experiments on 113 albino rats. The death following introduction of maximal amounts of potassium chloride was noted to supervene earlier than it did in animals receiving equivalent doses of potassium hydrocarbonate. Simultaneous introduction of sodium hydrocarbonate lowered the toxicity of both potassium hydrocarbonate and chloride. Morphological investigations revealed that toxic doses of potassium hydrocarbonate bring about shifts in the carbohydrate and lipids metabolism. Some mechanisms behind the action produced potassium chloride and hydrocarbonate are discussed.
Assuntos
Cloreto de Potássio/toxicidade , Potássio/toxicidade , Animais , Comportamento Animal/efeitos dos fármacos , Peso Corporal/efeitos dos fármacos , Carbonatos/toxicidade , Relação Dose-Resposta a Droga , Interações Medicamentosas , Eletrocardiografia , Coração/efeitos dos fármacos , Ratos , Sódio/farmacologiaRESUMO
The toxicity of potassium hydrocarbonate and chloride was compared in tests on 113 albino rats. It was noted that following introduction of maximal amounts of potassium chloride death occurred earlier in these animals than in the ones which received equivalent doses of potassium hydrocarbonate. Simultaneous administration of sodium hydrocarbonate reduced the toxicity of potassium hydrocarbonate and potassium chloride. Morphological investigations brought out that toxic doses of potassium hydrocarbonate led to shifts of the carbohydrate and lipids metabolism. Some mechanisms underlying the action of potassium chloride and potassium hydrocarbonate are discussed.
