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1.
J Emerg Med ; 56(5): e95-e101, 2019 May.
Artigo em Inglês | MEDLINE | ID: mdl-30904381

RESUMO

Program directors (PDs) are faced with an increasing number of applicants to emergency medicine (EM) and a limited number of positions. This article will provide candidates with insight to what PDs look for in an applicant. We will elaborate on the performance in the emergency medicine clerkship, interview, clinical rotations (apart from EM), board scores, Alpha Omega Alpha membership, letters of recommendation, Medical Student Performance Evaluation or dean's letter, extracurricular activities, Gold Humanism Society membership, medical school attended, research and scholarly projects, personal statement, and commitment to EM. We stress the National Resident Matching Program process and how, ultimately, selection of a residency is equally dependent on an applicant's selection process.


Assuntos
Seleção de Pessoal/métodos , Critérios de Admissão Escolar/tendências , Comportamento de Escolha , Medicina de Emergência/educação , Humanos , Estados Unidos
2.
Clin Toxicol (Phila) ; 57(11): 1073-1079, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-30806099

RESUMO

Context: Although cerebral perfusion (CP) is preserved across a wide range of mean arterial pressures (MAP) through cerebral-vascular autoregulation, the relationship between MAP and CP in refractory poison-induced cardiogenic shock (PICS) has never been studied. We compared the effects of therapies used in PICS: high-dose insulin (HDI), HDI plus norepinephrine (NE), and vasopressors alone (NE plus epinephrine (Epi)) on cerebral tissue oxygenation (PtO2). Methods: Fifteen swine were randomized to either HDI, HDI + NE, or NE + Epi. All animals received a propranolol infusion using an established model of toxicity. At primary toxicity (P1), defined as a 25% reduction in heart rate (HR) multiplied by MAP, the HDI and HDI + NE groups received HDI and the NE + Epi group received NE. Once a sustained MAP < 55 mmHg was reached (P2), the HDI group received saline (NS), the HDI + NE group received NE and the NE + Epi group received Epi until death or censoring. PtO2 and hemodynamic parameters including MAP, cardiac output (CO) and central venous pressure (CVP) were measured every 10 minutes. Glucose and potassium were measured at predetermined intervals. Results: Animals treated with HDI + NE maintained PtO2 over time more than the HDI-alone group. Due to rapid hemodynamic collapse, we were unable to analyze PtO2 data in the vasopressor only animals. Mean survival time was 1.9, 2.9 and 0.1 hours for the HDI, HDI + NE and NE + Epi groups, respectively. Survival time from P2 (sustained MAP <55 mmHg) to death or censoring was not different between HDI and HDI + NE groups. Conclusions: HDI + NE treatment was superior to HDI-alone at preserving PtO2 when MAP < 55 mmHg. We were unable to compare the PtO2 between the NE + Epi to the HDI or HDI + NE due to rapid decline in CO and death. If MAP is sustained at < 55 mmHg after maximizing HDI, adjunctive treatment with NE should be considered to preserve PtO2.


Assuntos
Insulina/administração & dosagem , Propranolol/toxicidade , Choque Cardiogênico/tratamento farmacológico , Vasoconstritores/farmacologia , Antagonistas Adrenérgicos beta/efeitos adversos , Animais , Pressão Arterial/efeitos dos fármacos , Modelos Animais de Doenças , Quimioterapia Combinada , Epinefrina/farmacologia , Estimativa de Kaplan-Meier , Norepinefrina/farmacologia , Oxigênio/metabolismo , Distribuição Aleatória , Choque Cardiogênico/induzido quimicamente , Choque Cardiogênico/mortalidade , Suínos , Fatores de Tempo
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