[The use of nimodipine in the acute period of a cerebral infarct]. / O primenenii nimodipina v ostrom periode infarkta mozga.

Before and after intravenous administration of 1-1.5 mg nimotop 18 patients with acute brain infarction underwent EEG, integral body rheography, computed tomography and measurement of regional volumetric cerebral circulation (RVCC). Nimotop appeared to increase RVCC in the infarction zone, especially in low initial RVCC levels. The drug induced a shift to EEG normalization and a hypotensive effect, cerebral hemodynamics remaining without changes. Nimodipine-type calcium antagonists favourably affect brain perfusion and bioelectric activity which is promising for application in acute cerebral infarction.

[Pharmacodynamic action of cavinton on regional volume blood flow, central hemodynamics and the bioelectric activity of the brain in the acute stage of a cerebral infarct]. / Farmakologicheskoe deistvie kavintona na regionarnyi ob''emnyi mozgovoi krovotok, tsentral'nuiu gemodinamiku i bioélektricheskuiu aktivnost' golovnogo mozga v ostroi stadii tserebral'nogo infarkta.

Forty-two patients with acute cerebral infarction were studied for the regional volumetric cerebral blood flow (rVCBF) and central hemodynamics (by integral rheography of the body) before and after the intravenous administration of 10 or 20 mg of cavinton (vinpocetine). It was found that in the absence of changes in the central hemodynamics an increase in the cerebral blood flow was the predominant characteristic, but parodoxical reactions were occasionally observed in the acute period of an extensive hemispherical infarct. The findings of quantitative frequency analysis of the EEG conducted in 40 patients correlated with the results of the study of the blood flow and indicated a more favourable prognosis in brain stem infarction or mild cortical infarction. Treatment of extensive cortical infarction was associated with cases of parodoxical deterioration of brain function which should be taken into account in prescribing cavinton to patients during the acute stage of cerebral infarction.

[Non-invasive method of measuring central hemodynamics in cerebral infarct patients]. / Neinvazivnyi metod izmereniia tsentral'noi gemodinamiki u bol'nykh s infarktom golovnogo mozga.

Changes in parameters of the central hemodynamics (CH) determined by integral rheography of the body (IRB) were analyzed in 39 patients with cerebral stroke (CS). It was found that despite a stable neurological and somatic status, parameters of cardiac contractivity diminished while the vascular tonus increased within the first 2 weeks of the disease. These alterations were more pronounced in obese patients. The authors believe that their data on an increased vascular tone indicate a compensatory function of the CH after the development of CS and suggest that the use of hypotensive drugs in such cases is inadvisable. A conclusion is drawn that IRB is an informative method of the dynamic examination of the CH in cerebral stroke patients.