The effects of a small-dose naloxone infusion on opioid-induced side effects and analgesia in children and adolescents treated with intravenous patient-controlled analgesia: a double-blind, prospective, randomized, controlled study.

Opioids are frequently associated with side effects such as nausea, vomiting, and pruritus. We hypothesized that a prophylactic, continuous small-dose naloxone infusion would reduce the incidence of opioid-induced side effects without affecting analgesia or opioid consumption. In this prospective, double-blind, randomized, controlled clinical trial, we studied 46 postoperative patients (M:F, 21:25), averaging 14 +/- 2.5 yr and 53 +/- 17 kg, at the start of morphine IV patient-controlled analgesia. Patients were randomized to either saline (control, n = 26) or naloxone 0.25 microg . kg(-1) . h(-1) (n = 20). We found that the incidence and severity of pruritus (77% versus 20%; P < 0.05) and nausea (70% versus 35%; P < 0.05) was significantly more frequent in the placebo group compared with the naloxone group. Morphine consumption (1.02 +/- 0.41 mg . kg(-1) . d(-1) versus 1.28 +/- 0.61 mg . kg(-1) . d(-1)), pain scores at rest (4 +/- 2 versus 3 +/- 2), and pain scores with coughing (6 +/- 2 versus 6 +/- 2) were not different. We conclude that, in children and adolescents, a small-dose naloxone infusion (0.25 microg . kg(-1) . h(-1)) can significantly reduce the incidence and severity of opioid-induced side effects without affecting opioid-induced analgesia. When initiating morphine IV patient-controlled analgesia for the treatment of moderate to severe pain, clinicians should strongly consider starting a concomitant small-dose naloxone infusion.

The association of intraoperative neuraxial anesthesia on anticipated admission to the intensive care unit.

STUDY OBJECTIVE: To determine whether use of intraoperative neuraxial anesthesia would decrease the frequency of ICU admission postoperatively in orthopedic patients. DESIGN: Retrospective chart review. SETTING: University hospital. MEASUREMENTS: We reviewed the data from all patients who underwent elective total knee or hip replacements from January 1, 1999 to September 30, 2000 and were preoperatively scheduled for ICU admission following surgery. We recorded patient demographic data, presence of comorbidities, intraoperative data, and location of postoperative recovery. MAIN RESULTS: Of the 361 patients having total knee and hip replacements, 88 patients were scheduled for postoperative ICU admission. Forty-five patients underwent neuraxial (epidural or spinal) anesthesia, 38 patients received general anesthesia, and 5 patients received a combination of both neuraxial and general anesthesia. Patients who received neuraxial anesthesia had a significantly lower rate of actual ICU admission when compared with those who received intraoperative general anesthesia (11/45 or 24% vs. 22/38 or 58%, p = 0.002). Patients who received neuraxial anesthesia had shorter anesthesia and surgical times when compared with those who received general anesthesia. CONCLUSIONS: Intraoperative neuraxial anesthesia in higher-risk patients undergoing elective hip or knee replacement surgery is associated with a decrease in anticipated ICU admission postoperatively. A causal relationship cannot be determined with this type of study and further research is needed to better understand this association.