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1.
Am J Epidemiol ; 158(1): 47-58, 2003 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-12835286

RESUMO

The EMF and Breast Cancer on Long Island Study (EBCLIS) was a case-control study designed to evaluate the possible association between exposure to electromagnetic fields (EMFs) and breast cancer. Eligible women were participants in the population-based Long Island Breast Cancer Study Project, were under 75 years of age at enrollment, were residentially stable, and were identified between August 1, 1996, and June 20, 1997. Of those eligible, 576 cases and 585 controls participated in EBCLIS (87% and 83%, respectively). In-home data collection included various spot and 24-hour EMF measurements, ground-current magnetic field measurements, wire mapping of overhead power lines servicing the home, and an interview. Odds ratios and 95% confidence intervals were based on multivariate logistic regression analyses. All odds ratios were close to 1 and nonsignificant. For the highest quartile of 24-hour EMF measurements, the odds ratio was 0.97 (95% confidence interval (CI): 0.69, 1.37) in the bedroom and 1.09 (95% CI: 0.78, 1.51) in the most lived-in room. For the highest exposure category of ground-current measurements, the odds ratio was 1.13 (95% CI: 0.88, 1.44) in the bedroom and 1.08 (95% CI: 0.85, 1.38) in the most lived-in room. These and other EBCLIS results agree with other recent reports of no association between breast cancer and residential EMF exposures.


Assuntos
Neoplasias da Mama/epidemiologia , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/estatística & dados numéricos , Adulto , Distribuição por Idade , Idoso , Neoplasias da Mama/etiologia , Estudos de Casos e Controles , Feminino , Humanos , Modelos Logísticos , Pessoa de Meia-Idade , New York/epidemiologia , Razão de Chances , Vigilância da População , Características de Residência
2.
Bioelectromagnetics ; 23(8): 622-8, 2002 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-12395418

RESUMO

Several authors have concluded that thermal electromagnetic noise will be of sufficient magnitude to overwhelm electric and/or magnetic fields induced by environmentally generated, power frequency electric and magnetic fields in the membranes of living cells located in the bodies of humans. Yet, there are research reports that indicate that living cells may respond to power frequency electric and/or magnetic field levels well below the limits set by these thermal noise arguments. The purpose of this study is to suggest that published thermal arguments may not make a full accounting of all membrane force fields of thermal origin, and that when such an accounting is made, the net thermal noise fields may be smaller in the power frequency range than previously thought. If this analysis is correct, there may be no thermal noise barrier that precludes the possibility of cellular membranes of human cells responding to environmental levels of power frequency electric or magnetic fields.


Assuntos
Membrana Celular/fisiologia , Membrana Celular/efeitos da radiação , Simulação por Computador , Campos Eletromagnéticos , Temperatura Alta , Modelos Biológicos , Condutividade Elétrica , Eletricidade , Eletrofisiologia/métodos , Exposição Ambiental , Humanos , Potenciais da Membrana , Sensibilidade e Especificidade , Processos Estocásticos
3.
Bioelectromagnetics ; 23(3): 177-88, 2002 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-11891747

RESUMO

An epidemiological study conducted by Savitz et al. reported that residential wire codes were more strongly associated with childhood cancer than were measured magnetic fields, a peculiar result because wire codes were originally developed to be a surrogate for residential magnetic fields. The primary purpose of the study reported here, known as the Back to Denver (BTD) study, was to obtain data to help in the interpretation of the original results of Savitz et al. The BTD study included 81 homes that had been occupied by case and control subjects of Savitz et al., stratified by wire code as follows: 18 high current configuration (HCC) case homes; 20 HCC control homes; 20 low current configuration (LCC) case homes; and 23 LCC control homes. Analysis of new data acquired in these homes led to the following previously unpublished conclusions. The home-averaged (i.e., mean of fields measured in subjects' bedrooms, family/living rooms, and rooms where meals normally eaten) spot 60 Hz, 180 Hz, and harmonic (i.e., 60-420 Hz) magnetic fields were associated with wire codes. The 180 Hz and harmonic components, but not the 60 Hz component, were associated with case/control status. Measured static magnetic fields were only weakly correlated (rapproximately 0.2) between rooms in homes. The BTD data provide little support for, but are too sparse to definitively test, the 1995 resonance hypothesis proposed by Bowman et al. Case and control homes had similar concentrations of copper in their tap water. Copper concentration was not associated with wire codes nor with the level of electric current carried by a home's water pipe. These results of the BTD study suggest that future case/control studies investigating power frequency magnetic fields might wish to include measurements of 180 Hz or harmonic magnetic fields in order to examine their associations (if any) with disease status.


Assuntos
Instalação Elétrica , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/efeitos adversos , Neoplasias/epidemiologia , Estudos de Casos e Controles , Criança , Colorado/epidemiologia , Cobre/análise , Interpretação Estatística de Dados , Instalação Elétrica/métodos , Instalação Elétrica/normas , Eletricidade , Exposição Ambiental/análise , Habitação , Humanos , Neoplasias/etiologia , Razão de Chances , Engenharia Sanitária , Abastecimento de Água/análise , Zinco/análise
4.
Bioelectromagnetics ; 23(1): 14-25, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11793402

RESUMO

A recent epidemiologic study reported associations between leukemia risk in children and their personal use of television (TV) sets, hair dryers, and stereo headsets, and the prenatal use by their mothers of sewing machines. To provide exposure data to aid in the interpretation of these findings, extremely and very low frequency (ELF and VLF) magnetic fields produced by a sample of each type of appliance were characterized in a field study of volunteers conducted in Washington DC and its Maryland suburbs. Questionnaire data regarding children's or mothers' patterns of usage of each type of appliance were also collected. ELF magnetic fields measured 10 cm from the nozzles of hair dryers were elevated over the ambient by a mean factor of 17 when these devices were in use. Fields near headsets being used to listen to music were not distinguishable from ambient levels except at frequencies below and well above 60 Hz and, even then, field levels were < 0.01 microT. Home sewing machines produced ELF magnetic fields that were elevated by a factor of 2.8 over ambient levels at the front surfaces of the lower abdomens of mothers. Estimated mean daily times of usage of hair dryers, stereo headsets, and sewing machines were 2.6, 19, and 17 minutes, respectively. These data and previously published data on TV sets, do not provide a consistent picture of increased (or decreased) leukemia risk in relation to increasing peak or time weighted average (TWA) ELF magnetic field exposure. The data could, however, conceivably be compatible with some more complex biophysical model with unknown properties. Overall, the results of this study provide little evidence supporting the hypothesis that peak or TWA ELF magnetic fields produced by appliances are causally related to the risk of childhood leukemia in children.


Assuntos
Magnetismo/efeitos adversos , Adolescente , Criança , Pré-Escolar , Eletrônica/instrumentação , Exposição Ambiental , Feminino , Humanos , Leucemia/etiologia , Gravidez , Efeitos Tardios da Exposição Pré-Natal , Fatores de Risco , Inquéritos e Questionários
5.
Bioelectromagnetics ; 23(1): 59-67, 2002 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-11793406

RESUMO

A problem frequently encountered when modeling the power frequency magnetic fields, B and A, produced by two sources is the necessity of estimating the root mean square (rms) magnitude of their sum, i.e., T = /B + A/, when the rms magnitudes, B and A, of the fields are specified by the model, but not necessarily their spatial directions, polarizations, and/or relative phase. The estimator Q = sqrt [B2+A2] was proposed many years ago for this purpose. The accuracy of this estimator is characterized in this paper. If it is known that B and A are approximately linearly polarized and in phase, the maximum bias (i.e., systematic) and random errors for Q used to estimate T are 6.1 and 35%, respectively, when B = A. These errors decrease as the difference between B and A increases. The bias and random errors are, respectively, 3.2 and 26% when B = 2A or A/2 and 0.2 and 5.8% when B = 10A or A/10. If the directions, relative phase, and polarizations of the two fields are unknown, Q has maximum bias and random errors of approximately 2.6 and approximately 23%, respectively, when B = A. These errors decrease to approximately 1.5 and approximately 18% when B =2 A or A/2 and approximately 0.08 and approximately 4.0% when B = 10A or A/10. If B and A are known to be linearly polarized and collinear, but with unknown phase between them, the maximum bias and random errors are 11 and 48%, respectively, when B = A. The errors are 5.1 and 32% when B = 2A or A/2 and 0.2 and 7.0% when B = 10A or A/10. Estimators for T with zero bias can be derived, but they are more complicated and increase overall accuracy very little.


Assuntos
Magnetismo/efeitos adversos , Fenômenos Biofísicos , Biofísica , Exposição Ambiental , Habitação , Humanos , Modelos Teóricos
6.
Am J Epidemiol ; 154(7): 591-600, 2001 Oct 01.
Artigo em Inglês | MEDLINE | ID: mdl-11581092

RESUMO

Exposure to 60-Hz magnetic fields may increase breast cancer risk by suppressing the normal nocturnal rise in melatonin. This 1994-1996 Washington State study investigated whether such exposure was associated with lower nocturnal urinary concentration of 6-sulfatoxymelatonin in 203 women aged 20-74 years with no history of breast cancer. Each woman was interviewed and provided data on the following for a 72-hour period at two different seasons of the year: 1) magnetic field and ambient light measured every 30 seconds in her bedroom, 2) personal magnetic field measured at 30-second intervals, and 3) complete nighttime urine samples on three consecutive nights. Lower nocturnal urinary 6-sulfatoxymelatonin level was associated with more hours of daylight, older age, higher body mass index, current alcohol consumption, and current use of medications classified as beta blockers, calcium channel blockers, or psychotropics. After adjustment for these factors, higher bedroom magnetic field level was associated with significantly lower urinary concentration of 6-sulfatoxymelatonin during the same night, primarily in women who used these medications and during times of the year with the fewest hours of darkness. These results suggest that exposure to nighttime residential 60-Hz magnetic fields can depress the normal nocturnal rise in melatonin.


Assuntos
Ritmo Circadiano , Iluminação , Magnetismo , Melatonina/urina , Antagonistas Adrenérgicos beta/farmacologia , Adulto , Fatores Etários , Idoso , Consumo de Bebidas Alcoólicas , Índice de Massa Corporal , Neoplasias da Mama/etiologia , Bloqueadores dos Canais de Cálcio/farmacologia , Feminino , Humanos , Melatonina/análogos & derivados , Menopausa , Pessoa de Meia-Idade , Psicotrópicos/farmacologia , Características de Residência , Fatores de Risco , Estações do Ano , Fumar
7.
Bioelectromagnetics ; 22(5): 294-305, 2001 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-11424152

RESUMO

Bowman et al. used epidemiologic data to test a model in which subjects were classified as being "in-resonance" or "not-in-resonance" for 60-Hz magnetic-field exposures depending on single static magnetic-field measurements at the centers of their bedrooms. A second paper by Swanson concluded that a single static magnetic-field measurement is insufficient to meaningfully characterize a residential environment. The main objective of this study was to investigate exposure-related questions raised by these two papers in two U.S. data sets, one containing single spot measurements of static magnetic fields at two locations in homes located in eight states, and the other repeated spot measurements (seven times during the course of one year) of the static magnetic fields at the centers of bedrooms and family rooms and on the surfaces of beds in 51 single-family homes in two metropolitan areas. Using Bowman's criterion, bedrooms were first classified as being in-resonance or not-in-resonance based on the average of repeated measurements of the static magnetic field measured on the bed where the presumed important exposure actually occurred. Bedrooms were then classified a second time using single spot measurements taken at the centers of bedrooms, centers of family rooms, or on the surfaces of beds, as would be done in the typical epidemiologic study. The kappa statistics characterizing the degree of concordance between the first (on-bed averages) and second (spot measurements) methods of assessing resonance status were 0.44, 0.33, and 0.67, respectively. This level of misclassification could significantly affect the results of studies involving the determination of resonance status.


Assuntos
Habitação , Magnetismo , Adolescente , Criança , Pré-Escolar , Feminino , Humanos , Magnetismo/efeitos adversos , Masculino , Modelos Teóricos , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Fatores de Risco , Estações do Ano
8.
Bioelectromagnetics ; 22(4): 232-45, 2001 May.
Artigo em Inglês | MEDLINE | ID: mdl-11298385

RESUMO

Considerable interest has developed during the past ten years regarding the hypothesis that living organisms may respond to temporal variability in ELF magnetic fields to which they are exposed. Consequently, methods to measure various aspects of temporal variability are of interest. In this paper, five measures of temporal variability were examined: Arithmetic means (D(mean)) and rms values (D(rms)) of the first differences (i.e., absolute value of the difference between consecutive measurements) of magnetic field recordings; "standardized" forms of D(rms), denoted RCMS, obtained by dividing D(rms) by the standard deviations of the magnetic field data; and mean (F(mean)) and rms (F(rms)) values of fractional first differences. Theoretical investigations showed that D(mean) and D(rms) are virtually unaffected by long-term systematic trends (changes) in exposure. These measures thus provide rather specific measures of short-term temporal variability. This was also true to a lesser extent for F(mean) and F(rms). In contrast, the RCMS metric was affected by both short-term and long-term exposure variabilities. The metrics were also investigated using a data set consisting of twice-repeated two-calendar-day recordings of bedroom magnetic fields and personal exposures of 203 women residing in the western portion of Washington State. The predominant source of short-term temporal variability in magnetic field exposures arose from the movement of subjects through spatially varying magnetic fields. Spearman correlations between TWA bedroom magnetic fields or TWA personal exposures and five measures of temporal variability were relatively low. Weak to moderate levels of correlation were observed between temporal variability measured during two different sessions separated in time by 3 or 6 months. We conclude that first difference and fractional difference metrics provide specific and fairly independent measures of short-term temporal variability. The RCMS metric does not provide an easily interpreted measure of short-term or long-term temporal variability. This last result raises uncertainties about the interpretation of published studies that use the RCMS metric.


Assuntos
Poluição do Ar em Ambientes Fechados , Campos Eletromagnéticos , Exposição Ambiental , Habitação , Humanos , Modelos Teóricos , Respiração , Sono , Estatísticas não Paramétricas , Fatores de Tempo , Viagem
9.
Epidemiology ; 11(2): 189-98, 2000 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-11021619

RESUMO

In contrast with several previous studies, our recent large case-control study found little association between childhood acute lymphoblastic leukemia (ALL) and electric-power-line wire codes. Here we examine internal evidence from our study to assess the possibility that selection bias and/or confounding may have affected the findings. We compared the relation between childhood ALL and wire codes and direct measurements of magnetic fields in subjects who participated in all phases of the study with the relation in all subjects, including those who declined to allow access inside the home. We found that the odds ratio for ALL among those living in homes with very high current configurations increased by 23% when 107 "partial participants" were excluded. We found similar, but slightly smaller, increases in the odds ratios when we performed the same comparisons using direct measurements of magnetic fields, excluding subjects who allowed only a measurement outside the front door. "Partial participants" tended to be characterized by lower socioeconomic status than subjects who participated fully, suggesting possible selection bias. We also examined the relation between a large number of potential confounding variables and both proxy and direct measurements of magnetic fields. Univariate adjustment for individual variables changed the odds ratio for ALL by less than 8%, while simultaneous adjustment for several factors reduced the estimate by a maximum of 15%. We conclude that while confounding alone is unlikely to be an important source of bias in our own and previous studies of magnetic fields, selection bias may be more of a concern, particularly in light of the generally low response rates among controls in case-control studies.


Assuntos
Instalação Elétrica/normas , Campos Eletromagnéticos/efeitos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Estudos de Casos e Controles , Criança , Pré-Escolar , Fatores de Confusão Epidemiológicos , Feminino , Habitação , Humanos , Modelos Logísticos , Masculino , Razão de Chances , Viés de Seleção , Classe Social
10.
Epidemiology ; 11(6): 624-34, 2000 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-11055621

RESUMO

We obtained original individual data from 15 studies of magnetic fields or wire codes and childhood leukemia, and we estimated magnetic field exposure for subjects with sufficient data to do so. Summary estimates from 12 studies that supplied magnetic field measures exhibited little or no association of magnetic fields with leukemia when comparing 0.1-0.2 and 0.2-0.3 microtesla (microT) categories with the 0-0.1 microT category, but the Mantel-Haenszel summary odds ratio comparing >0.3 microT to 0-0.1 microT was 1.7 (95% confidence limits = 1.2, 2.3). Similar results were obtained using covariate adjustment and spline regression. The study-specific relations appeared consistent despite the numerous methodologic differences among the studies. The association of wire codes with leukemia varied considerably across studies, with odds ratio estimates for very high current vs low current configurations ranging from 0.7 to 3.0 (homogeneity P = 0.005). Based on a survey of household magnetic fields, an estimate of the U.S. population attributable fraction of childhood leukemia associated with residential exposure is 3% (95% confidence limits = -2%, 8%). Our results contradict the idea that the magnetic field association with leukemia is less consistent than the wire code association with leukemia, although analysis of the four studies with both measures indicates that the wire code association is not explained by measured fields. The results also suggest that appreciable magnetic field effects, if any, may be concentrated among relatively high and uncommon exposures, and that studies of highly exposed populations would be needed to clarify the relation of magnetic fields to childhood leukemia.


Assuntos
Instalação Elétrica , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/efeitos adversos , Leucemia/etiologia , Criança , Humanos
11.
Am J Epidemiol ; 152(1): 20-31, 2000 Jul 01.
Artigo em Inglês | MEDLINE | ID: mdl-10901326

RESUMO

Data collected by the National Cancer Institute-Children's Cancer Group were utilized to explore various metrics of magnetic field levels and risk of acute lymphoblastic leukemia (ALL) in children. Cases were aged 0-14 years, were diagnosed with ALL during 1989-1993, were registered with the Children's Cancer Group, and resided in one home for at least 70 percent of the 5 years immediately prior to diagnosis. Controls were identified by using random digit dialing and met the same residential requirements. With 30-second ("spot") measurements and components of the 24-hour measurement obtained in the subject's bedroom, metrics evaluated included measures of central tendency, peak exposures, threshold values, and measures of short-term temporal variability. Measures of central tendency and the threshold measures showed good-to-high correlation, but these metrics correlated less well with the others. Small increases in risk (ranging from 1.02 to 1.69 for subjects in the highest exposure category) were associated with some measures of central tendency, but peak exposures, threshold values, measures of short-term variability, and spot measurements demonstrated little association with risk of childhood ALL. In general, risk estimates were slightly higher for the nighttime (10 p.m.-6 a.m.) interval than for the corresponding 24-hour period.


Assuntos
Campos Eletromagnéticos , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Adolescente , Criança , Pré-Escolar , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental , Feminino , Humanos , Lactente , Masculino , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia
12.
Am J Epidemiol ; 151(5): 512-5, 2000 Mar 01.
Artigo em Inglês | MEDLINE | ID: mdl-10707920

RESUMO

In the National Cancer Institute/Children's Cancer Group case-control study of childhood acute lymphoblastic leukemia (1989-1993), living in a home with a high-voltage wire code was not associated with disease risk. To further investigate risk near power lines, the authors analyzed distance to transmission and three-phase primary distribution lines within 40 m of homes and created an exposure index of distance and strength of multiple power lines (408 case-control pairs). Neither distance nor exposure index was related to risk of childhood acute lymphoblastic leukemia, although both were associated with in-home magnetic field measurements. Residence near high-voltage lines did not increase risk.


Assuntos
Fontes de Energia Elétrica/efeitos adversos , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/efeitos adversos , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Adolescente , Criança , Humanos , Incidência , Estudos Retrospectivos , Fatores de Risco , Estados Unidos/epidemiologia
13.
Bioelectromagnetics ; 21(3): 197-213, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10723020

RESUMO

Recent interest in the transient magnetic field events produced by electrical switching events in residential and occupational environments has been kindled by the possibility that these fields may explain observed associations between childhood cancer and wire codes. This paper reports the results of a study in which the rate of occurrence of magnetic field events with 2-200 kHz frequency content were measured over 24 h or longer periods in 156 U.S. residences. A dual-channel meter was developed for the study that, during 20 s contiguous intervals of time, counted the number of events with peak 2-200 kHz magnetic fields exceeding thresholds of 3. 3 nT and 33 nT. Transient activity exhibited a distinct diurnal rhythm similar to that followed by power frequency magnetic fields in residences. Homes that were electrically grounded to a conductive water system that extended into the street and beyond, had higher levels of 33 nT channel transient activity. Homes located in rural surroundings had less 33 nT transient activity than homes in suburban/urban areas. Finally, while transient activity was perhaps somewhat elevated in homes with OLCC, OHCC, and VHCC wire codes relative to homes with underground (UG) and VLCC codes, the elevation was the smallest in VHCC and the largest in OLCC homes. This result does not provide much support for the hypothesis that transient magnetic fields are the underlying exposure that explains the associations, observed in several epidemiologic studies, between childhood cancer and residence in homes with VHCC, but not OLCC and OHCC, wire codes.


Assuntos
Eletricidade , Campos Eletromagnéticos , Exposição Ambiental , Habitação , Magnetismo , Criança , Ritmo Circadiano , Intervalos de Confiança , Condutividade Elétrica , Instalação Elétrica/classificação , Instalação Elétrica/métodos , Instalação Elétrica/normas , Eletricidade/efeitos adversos , Campos Eletromagnéticos/efeitos adversos , Habitação/classificação , Habitação/normas , Humanos , Indústrias , Modelos Logísticos , Magnetismo/efeitos adversos , Neoplasias/epidemiologia , Neoplasias Induzidas por Radiação/epidemiologia , Razão de Chances , População Rural , População Suburbana , Fatores de Tempo , Estados Unidos/epidemiologia , População Urbana , Abastecimento de Água
14.
Bioelectromagnetics ; 21(3): 214-27, 2000 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-10723021

RESUMO

Two epidemiologic studies have reported increased risk of childhood leukemia associated with the length of time children watched television (TV) programs or played video games connected to TV sets. To evaluate magnetic field exposures resulting from these activities, the static, ELF, and VLF magnetic fields produced by 72 TV sets used by children to watch TV programs and 34 TV sets used to play video games were characterized in a field study conducted in Washington DC and its Maryland suburbs. The resulting TV-specific magnetic field data were combined with information collected through questionnaires to estimate the magnetic field exposure levels associated with TV watching and video game playing. The geometric means of the ELF and VLF exposure levels so calculated were 0.0091 and 0.0016 microT, respectively, for children watching TV programs and 0.023 and 0.0038 microT, respectively, for children playing video games. Geometric means of ambient ELF and VLF levels with TV sets turned off were 0.10 and 0.0027 microT, respectively. Summed over the ELF frequency range (6-3066 Hz), the exposure levels were small compared to ambient levels. However, in restricted ELF frequency ranges (120 Hz and 606-3066 Hz) and in the VLF band, TV exposure levels were comparable to or larger than normal ambient levels. Even so, the strengths of the 120 Hz or 606-3066 Hz components of TV fields were small relative to the overall ambient levels. Consequently, our results provide little support for a linkage between childhood leukemia and exposure to the ELF magnetic fields produced by TV sets. Our results do suggest that any future research on possible health effects of magnetic fields from television sets might focus on the VLF electric and magnetic fields produced by TV sets because of their enhanced ability relative to ELF fields to induce electric currents.


Assuntos
Campos Eletromagnéticos , Exposição Ambiental , Magnetismo , Televisão , Jogos de Vídeo , Adolescente , Radiação de Fundo , Criança , Pré-Escolar , District of Columbia , Eletricidade/efeitos adversos , Campos Eletromagnéticos/efeitos adversos , Humanos , Leucemia/etiologia , Leucemia Induzida por Radiação/etiologia , Magnetismo/efeitos adversos , Maryland , Doses de Radiação , Fatores de Risco , Inquéritos e Questionários , Fatores de Tempo , Jogos de Vídeo/efeitos adversos
15.
Occup Environ Med ; 56(8): 562-6, 1999 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-10492656

RESUMO

OBJECTIVES: To investigate the impact of measuring a single home then imputing information from another home among subjects who lived in two homes in a subset of the National Cancer Institute/Children's Cancer Group (NCI/CCG) investigation of residential exposure to magnetic fields and risk of childhood leukaemia. METHODS: Each subject's summary time weighted average (TWA) exposure was derived from measurements of two homes, weighted by the fraction of the reference period lived in the residence. The three cost efficient field work strategies examined were measuring: (a) the longer lived in home; (b) the currently lived in home; and (c) the former lived in home. Two different methods were used for imputing the missing values: (a) control mean imputation, (b) status specific mean imputation. The subject's summary exposure to magnetic fields estimated with each approach was compared with the subject's TWA calculated from measurements in both homes. The association between estimated exposure to magnetic fields and the risk of leukaemia under different approaches was examined with unconditional logistic regression analysis. RESULTS: The Pearson correlation coefficient between the two measurements within subjects was 0.31 (p < 10(-4), indicating a lack of independence of measurements. Differences were found between mean exposures in current and former homes of cases, and between longer and shorter lived in homes of controls. All methods with measurements from one of the homes in conjunction with imputation of measurements for the second home led to marked attenuation of risk estimates at the highest exposure category, particularly when measurements from current homes were used and those from former homes were imputed. CONCLUSION: Results argue against attempting to estimate lifetime magnetic field exposure from imputed values derived from current residences to fill in gaps caused by unmeasured residences previously lived in.


Assuntos
Campos Eletromagnéticos , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Medição de Risco , Viés , Exposição Ambiental , Humanos , Modelos Logísticos , Características de Residência , Estados Unidos/epidemiologia
16.
Bioelectromagnetics ; 20(5): 306-18, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10407516

RESUMO

The Wertheimer-Leeper wire code, originally developed as a surrogate for magnetic-field exposure, has been associated with childhood leukemia in several epidemiologic investigations. However, these and other studies indicate that most between-residence variability in measured magnetic fields remains unexplained by wire codes. To better understand this remaining variability, engineering and demographic data were examined for 333 underground (UG) and very-low current configuration (VLCC) single-family or duplex residences, selected from a database of nearly 1000 residences specifically because their magnetic fields are most likely affected negligibly by overhead power lines. Using linear regression techniques, four factors predictive of the log-transformed residential field were identified: the square-root of the 24-h average net service drop current (this current is equivalent to the current in the grounding system), the log of the number of service drops on the same secondary serving the residence, residence age (four categories), and area type (rural, suburban, or urban). Complete data on ground current and service drops, the two factors with the strongest individual relationships to measured fields, were available for only half of the residences in the sample. However, these data were determined to be "missing at random" according to established statistical criteria. The full-sample or "composite" models thus relied on a method similar to regression imputation, accounting for missing data with binary dummy variables. When applied to the samples from which they were derived, these models accounted for 25% of the variance of the log-spot-measured magnetic field values in the full sample, while models that considered only those residences with complete data (n = 167) explained about 35%. The model validated well against a sample of 201 ordinary low current configuration (OLCC) homes selected from the same database.


Assuntos
Magnetismo/efeitos adversos , Criança , Bases de Dados Factuais , Eletricidade , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental , Habitação , Humanos , Leucemia/etiologia , Modelos Teóricos , Reprodutibilidade dos Testes
18.
Bioelectromagnetics ; 20(4): 244-54, 1999.
Artigo em Inglês | MEDLINE | ID: mdl-10230938

RESUMO

The purpose of this paper is to review measurements of residential power-frequency magnetic fields made in different countries and to determine whether average magnetic fields away from appliances are higher in some countries than in others. The paper includes 27 studies reporting measurements of residential magnetic fields in samples of homes: 14 from North America, 5 from the United Kingdom, and 8 from other European countries. Various factors that might make the results from individual studies unrepresentative of average fields in the relevant country are identified and discussed. Because distributions of magnetic fields generally are approximately log-normal, they are summarised by their geometric means. The best estimate of the geometric means of long-term average background fields in the United States is 60-70 nT and in the United Kingdom approximately 36-39 nT. In other countries, there are insufficient studies to draw firm conclusions on average fields. Measurements of personal exposure are higher than measurements of background fields, perhaps because they include exposures from appliances and other sources in the home. The ratio of personal exposure to background field seems, on average, to be approximately 1.4.


Assuntos
Exposição Ambiental , Habitação , Magnetismo , Viés , Campos Eletromagnéticos , Europa (Continente) , Utensílios Domésticos , Humanos , Modelos Lineares , América do Norte , Reino Unido
19.
Am J Ind Med ; 34(6): 574-80, 1998 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-9816415

RESUMO

BACKGROUND: Flight crews are exposed to elevated levels of cosmic radiation and to magnetic fields generated by the aircraft's electrical system. The purpose of this study was to quantify these two occupational exposures. METHODS: Magnetic fields were measured during 37 flights (23 in the cockpit and 14 in the cabin) using an Emdex Lite personal dosimeter. All cockpit measurements were taken on the B737/200. Cabin measurements were taken in several aircraft types, including the B737, B757, DC9, and L1011. Cosmic radiation was computer estimated for 206 flights using the Federal Aviation Administration's program CARI-3C. RESULTS: Magnetic field levels in the cockpit had a mean value of approximately 17 milliGauss (mG), while cabin measurements were lower (mean values of approximately 3 or less in economy, 6 in first class, 8 in front serving areas). Cosmic radiation equivalent dose rates to bone marrow and skeletal tissue ranged from 0.3 to 5.7 microsieverts per hour. CONCLUSIONS: Elevated magnetic field levels in front serving areas and the cockpit suggest the need for further study to evaluate long-term exposure to flight crew members who work in these areas. Cosmic radiation levels are well below occupational limits for adults, but may require some pregnant flight crew members to adjust their flying time or routes.


Assuntos
Medicina Aeroespacial , Aeronaves , Radiação Cósmica , Campos Eletromagnéticos , Exposição Ocupacional , Humanos
20.
Occup Environ Med ; 55(5): 333-9, 1998 May.
Artigo em Inglês | MEDLINE | ID: mdl-9764111

RESUMO

OBJECTIVES: To investigate the reproducibility of wire codes to characterise residential power line configurations and to determine the extent to which wire codes provide a proxy measure of residential magnetic field strength in a case-control study of childhood leukaemia conducted in nine states within the United States. METHODS: Misclassification of wire codes was assessed with independent measurements by two technicians for 187 residences. The association between categories of wire code and measured level of magnetic field was evaluated in 858 residences with both a wire code measurement and a 24 hour measurement of the magnetic field in the bedroom. The strength of the association between category of wire code and risk of leukaemia was examined in two regions with different average levels of magnetic field in homes with high categories of wire code. RESULTS: The reproducibility of any of three different classifications of wire codes was excellent (kappa > or = 0.89). Mean and median magnetic fields, and the percentage of homes with high magnetic fields increased with increasing category for each of the wire code classification schemes. The size of the odds ratios for risk of leukaemia and high categories of wire code did not reflect the mean levels of the magnetic field in those categories in two study regions. CONCLUSION: Misclassification of categories of wire code is not a major source of bias in the study. Wire codes provide a proxy measure of exposure to residential magnetic fields. If magnetic fields were a risk factor for leukaemia, however, there would be some attenuation of risk estimates based on wire codes because of misclassification of exposure to magnetic fields at both extremes of the wire code range. The lack of an association between high categories of wire code and risk of leukaemia cannot be explained by a failure of the wire code classification schemes to estimate exposure to magnetic fields in the study area.


Assuntos
Instalação Elétrica , Campos Eletromagnéticos/efeitos adversos , Exposição Ambiental/efeitos adversos , Viés , Criança , Pré-Escolar , Instalação Elétrica/classificação , Humanos , Leucemia Induzida por Radiação/epidemiologia , Leucemia Induzida por Radiação/etiologia , Razão de Chances , Leucemia-Linfoma Linfoblástico de Células Precursoras/epidemiologia , Leucemia-Linfoma Linfoblástico de Células Precursoras/etiologia , Reprodutibilidade dos Testes , Medição de Risco , Fatores de Risco , Estados Unidos/epidemiologia
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