1.
Trends Endocrinol Metab
; 27(5): 242-244, 2016 05.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27037211
RESUMO
Molecular features of castration-resistant neuroendocrine prostate cancer (CRPC-NE) are not well characterized. A recent study that investigated genomic aberrations of CRPC-NE tumors suggests their clonal evolution from CRPC adenocarcinoma. Furthermore, the existence of a distinct DNA methylation profile in CRPC-NE implicates a critical role for epigenetic modification in the development of CRPC-NE.