Wastewater-based epidemiology: a new frontier for tracking environmental persistence and community transmission of COVID-19.

Recent research in many parts of the world has pointed towards evidence of SARS-CoV-2 RNA in both treated and raw municipal wastewater discharged by communities. Therefore, concerns regarding it being a possible enteric virus are abundant. Past history of SARS-CoV-1 outbreaks and viral survival information helps in establishing information regarding possible viral infectivity and survival of SARS-CoV-2. The paper examines the existing strategies and techniques including the efficacy of laboratory-based RT-qPCR technique for tracking environmental persistence and community transmission of COVID-19. Analysis of studies targeting untreated and treated wastewater as source of samples is carried out. The analysis shows that untreated samples were mostly positive for SARS-CoV-2 RNA in the target studies. Infectivity estimation from viral load data was found to be about two orders of magnitude higher than actual case data in one of the studies. Additionally, relevant research on environmental survivability of SARS-CoV-2 and possible gaps are examined. Biosensors and excretion metabolite tracking in viral detection are also examined, which hold tremendous importance for future research. Wastewater-based epidemiology (WBE) shows incredible promise in the near future for tracking environmental persistence and community transmission of highly infectious diseases such as SARS-CoV-2. With limited research available on SARS-CoV-2 with regard to WBE, it is imperative that focus be established on the evidence-based targeted studies.

Therapeutic Effect of Cereal Grains: A Review.

Over the last few decades, life style changes have resulted in drastic increase in the incidence of diabetes all over the world, especially in the developing countries. Oral hypoglycemic agents and insulin form the main stay in controlling diabetes but they have prominent side effects and fail to significantly alter the course of diabetic complications. Appropriate diet and exercise programs that form a part of lifestyle modifications have proven to be greatly effective in the management of this disease. Dietary therapy is showing a bright future in the prevention and treatment of diabetes. Cereal grains which form the staple diet for humans in most of the countries are increasingly being used to treat diabetes and other associated disorders in view of their anti-diabetic and anti-lipidemic potential. Given this background, this paper reviews the possible mechanisms of lowering blood sugar and cholesterol levels possessed by various commonly consumed cereal grains. It is concluded that cereal grains are not only the potential sources of energy but also possess the therapeutic role in preventing metabolic disorders and decreasing the risk factors for cardiovascular and renal diseases.

Effect of processing on mycotoxin content in grains.

Mycotoxins that commonly occur in cereal grains and other products can contaminate finished processed foods on account of their high toxicity. The mycotoxins that are commonly associated with food grains include aflatoxins, ochratoxin A, fumonisins, deoxynivalenol, and zearalenone. Various food-processing operations include sorting, trimming, cleaning, cooking, baking, frying, roasting, flaking, and extrusion that have variable effects on mycotoxins. The nature of the processing operation viz. physical, chemical, or thermal plays an important role in this; usually, the processes that utilize the higher temperatures have greater effects on mycotoxin dissipation. In general, the processes are known to reduce mycotoxin concentrations significantly, but do not eliminate them completely. However, roasting and extrusion processing result in lowest mycotoxin concentrations, since these involve higher temperatures. It is observed that very high temperatures are needed to bring about high reduction in mycotoxin concentrations, approaching acceptable background levels. The treatment with chemicals like ammonia, bicarbonate, citric acid, or sodium bisulfite is also effective in resulting in significant decline in mycotoxin concentrations.

Antidiabetic potential of commonly consumed legumes: a review.

Over the last few decades, lifestyle changes have resulted in a drastic increase in the incidence of diabetes all over the world, especially in the developing countries. Oral hypoglycemic agents and insulin form the mainstay in controlling diabetes, but they have prominent side effects and fail to significantly alter the course of diabetic complications. Appropriate diet and exercise programs that form a part of lifestyle modifications have proven to be greatly effective in the management of this disease. Dietary therapy is showing a bright future in the prevention and treatment of diabetes. Legumes, owing to their high nutritive value, are increasingly being used in dietetic formulations in the treatment and prevention of diabetes on account of their antidiabetic potential. Given this background, this paper reviews the glucose- and lipid-lowering action possessed by various commonly consumed legumes through several animal and human studies. It is concluded that the various legumes not only have varying degrees of antidiabetic potential but are also beneficial in decreasing the risk factors for cardiovascular and renal disease.

An assessment of structure and toxicity correlation in organochlorine pesticides.

Organochlorines are the most successful, profitably utilized and commercialized group of pesticides. They have gained huge popularity and prominence in a short span of time by virtue of their ability to control almost all kinds of pests including insect, fungi, rodent, etc. The toxicity of an individual pesticide to the pests is predominantly determined by its structure, the different moieties attached to parent compound, their spatial arrangements within molecule, nature of substituents, polarity, symmetry and asymmetry of molecules, the solubility and sorption values. The present paper discusses the toxicity in terms of LD(50) of organochlorine pesticides on the basis of their structures. Further, the mode of action of these pesticides has been discussed for a better understanding of toxicity. Finally an attempt has been made to understand the structure toxicity relationship in organochlorine pesticides.