1.
J Pharm Sci
; 72(10): 1215-7, 1983 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6644576
RESUMO
The formation of an inclusion compound by beta-cyclodextrin with hydrocortisone has been studied by proton magnetic resonance (1H-NMR) and phase solubility analysis. The magnitude of the chemical shifts of the interior and exterior beta-cyclodextrin protons in the presence of hydrocortisone indicated that hydrocortisone is included within the beta-cyclodextrin cavity and probably interacts with protons on the edge of the torus. The overall stoichiometry of the inclusion compound was not a single, simple relationship, but was unusual in that it was variable and apparently dependent on the relative amounts of hydrocortisone and beta-cyclodextrin in the system.
Assuntos
Ciclodextrinas/análise , Dextrinas/análise , Hidrocortisona/análise , Amido/análise , beta-Ciclodextrinas , Química Farmacêutica , Espectroscopia de Ressonância Magnética , Conformação Molecular , Solubilidade , Termodinâmica
2.
Acta Pharm Suec
; 15(1): 1-12, 1978.
Artigo
em Inglês
| MEDLINE
| ID: mdl-645364
3.
J Pharm Pharmacol
; 26 Suppl: 62P-63P, 1974 Dec.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4156741