RESUMO
There have been experimentally studied the antibacterial properties of the preparation "gentacycol" developed in the research institute of antibiotics. Its effective agent is gentamycin and as the matrix of a carrier modified collagen is used. It is indicated that in vitro and at implantation in preliminary infected ordinary and gunshot osseous wounds in rabbits and dogs gentacycol inhibits the growth of aerobic and, that is especially important, anaerobic microflora, limits the development of inflammatory Process and stimulates, to a certain extent, reparative osteogenesis. The obtained data allows to recommend gentacycol application for prophylaxis of wound infection in treatment of gunshot limb bone injuries.
Assuntos
Traumatismos do Braço/complicações , Infecções Bacterianas/prevenção & controle , Modelos Animais de Doenças , Fraturas Ósseas/complicações , Gentamicinas/administração & dosagem , Traumatismos da Perna/complicações , Infecção dos Ferimentos/prevenção & controle , Ferimentos por Arma de Fogo/complicações , Animais , Traumatismos do Braço/microbiologia , Infecções Bacterianas/etiologia , Cães , Avaliação Pré-Clínica de Medicamentos , Membro Anterior/lesões , Membro Anterior/microbiologia , Fraturas Ósseas/microbiologia , Membro Posterior/lesões , Membro Posterior/microbiologia , Humanos , Traumatismos da Perna/microbiologia , Coelhos , Infecção dos Ferimentos/etiologia , Ferimentos por Arma de Fogo/microbiologiaRESUMO
The authors have proposed the idea of joint motion realization by means of rolling of one joint surface over the other one. It allows to pass over an unsolved yet problem of cartilage restoration and normal gliding in the affected joint. It has been developed a model at the knee joint of a dog, which provides for resection of the joint surfaces according to semicylinder and plane shape and introduction of lavsane bands to hold and direct movement of the articular ends. 34 dogs have been subjected to experimental operations. There was achieved good and satisfactory joint and limb function with 25 of them. Biomechanical investigation allowed to prove joint mobility and limb supporting ability.