[Extra-islet cells of pancreas during the diabetes of alloxan and after the action of plaferon].

Using the methods of light and electron microscopy, pancreas was studied in the experimental model of alloxan diabetes (AD) at various times of the experiment (1 and 6 month) at different degrees of AD and after the action of plaferon. The special emphasis was made on display of compensatory changes that is opportunity of occurrence in extra-islet cells special granules, characteristic for insulin producing B-cells. During the development of pathological processes, there were detected intermediate cells including exocrine and endocrine granules. Some of these cells were located near the acini and some of them were in close contact with duct cells. It is suggested that these intermediate extra-islet cells are especial cells with high functional activity, they are transitional form during the processes of transformation into endocrine ones, possibly these cells are precursors of islet cells. It is possible, that plaferon acts on processes of transformation and differentiation of extra-islet cells and takes part in neogenesis of B-cells.

[Stimulation of proliferative and metabolic processes in the liver after administration of allogeneic hepatocytes]. / Stimuliatsiia proliferativnykh i metabolicheskikh protsessov v pecheni posle vvedeniia allogennykh gepatotsitov.

The interconnection of morpho-functional changes of liver and cellular capacity to synthesize RNA and DNA in condition of the acute liver failure (ALF) and after the administration of the newborn allogenic hepatocytes (NAH) was studied by the autoradiographic method. The administration of NAH prevents, in part, the ischemic cell death and is efficient in the stimulation of the liver regeneration in ALF; it increases metabolic and proliferative activity of hepatocytes as well as of reticulo-endothelial cells.

[The stimulation of regenerative processes in the liver in acute liver failure]. / Stimuliatsiia vosstanovitel'nykh protsessov v pecheni pri ostroi pechenochnoi nedostatochnosti.

The efficiency of the newborn allogenic hepatocytes (NAH) in the treatment of the acute liver failure (ALF) in dogs is studied histologically, histochemically and ultrastructurally. The administration of NAH prevents, in part, the ischemic cell death and is efficient in the stimulation of the liver regeneration in ALF. NAH enhance hepatocyte and Kupffer cell proliferation, reduce the number of degenerative and necrotic foci, increase the number of cell organelles, their volume, compensate the function of the damaged liver, facilitate the morpho-functional restoration of the recipient ischemically damaged liver.