1.
Org Lett
; 7(24): 5489-91, 2005 Nov 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16288538
RESUMO
[reaction: see text] A rhodium(III) catalyst for asymmetric transfer hydrogenation of ketones has been designed. The incorporation of a tethering group between the diamino group and the cyclopentadienyl unit provides extra stereochemical rigidity. The catalyst is capable of enantioselective reduction of a range of ketones in excellent ee using formic acid/triethylamine as both the solvent and the reducing agent.