1.
Bioorg Med Chem Lett
; 14(11): 2969-72, 2004 Jun 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-15125970
RESUMO
Protein kinase C (PKC) is a family of enzymes, which play important roles in intracellular signal transduction. To examine the distance between the two ligand binding sites (C1A and C1B) of PKC, we designed and synthesized two series of isobenzofuranone dimers. Peak binding activities were observed for the C3-acyl chain dimers having a C10-C12 linker and for the C7 dimers having a C14-C16.