An observational study of oral functions in patients aged from 20 to 49 years.

PURPOSE: The purpose of this study was to analyze oral functions (MOF: maximum occlusal force; MTP: maximum tongue pressure; and MF: masticatory function) in Eichner A subjects aged from 20 to 49 years. METHODS: The data of three oral functions in Eichner A patients aged from 20 to 49 years were extracted. The mean values, subjects with lower values than the thresholds, and the differences among ages, and between sexes were investigated retrospectively. RESULTS: Although the mean values of these oral functions in 183 subjects were higher than the thresholds, the numbers of the subjects with lower values than the thresholds were 30 in MTP, 19 in MOF, and only three in MF. No significant effects of ages on all oral functions were identified and all functions in males were significantly higher than those in females. The subjects whose two functions were lower than the thresholds were nine females, eight of whom were associated with malalignment. CONCLUSION: Although the mean values of oral functions were higher than the thresholds, some patients showed lower values, especially in MOF and MTP, even though they were unaware of any inconvenience. Patients with malalignment might be associated with declined oral functions.

TDLAS-based water vapor monitoring in narrow channels of polymer electrolyte fuel cells using a single-ended fiber-optic sensor.

The dehydration of electrolyte membranes in polymer electrolyte fuel cells (PEFCs) operating under low-humidity conditions is a critical issue for achieving their high efficiency and high power density. To reduce the membrane dryout, it's necessary to investigate and control the water transport within working fuel cells. This study developed a single-ended fiber-optic sensor based on tunable diode laser absorption spectroscopy (TDLAS) and applied it to the real-time monitoring of the water vapor concentration in the narrow flow channel of a PEFC. The newly proposed wavelength modulation spectroscopy (WMS) technique enabled to quantify the mole fraction of water in the channel over the wide concentration range with high accuracy. The in-situ TDLAS measurement in the PEFC during a low-humidity and load-change operation revealed that the dynamic change of cell voltage is strongly correlated to the dry-wet transition in the anode channel.

Brainwave activities reflecting depressed mood: a pilot study.

Early diagnosis and treatment of depression are desirable but currently difficult due to a lack of established biomarkers. Although biomarkers for depression based on electroencephalogram (EEG) data have long been explored, most existing methods are thought to capture cognitive decline caused by depression and are unsuccessful in detecting signs of depression. Here we report that some brainwave activities involving phase resetting reflect the depressed mood at the time, which can be easily monitored by measuring the resting EEG with eyes closed for 1 min with a few electrodes. We instructed 10 participants (nine healthy and one diagnosed with depression, aged 18-34) to record their EEG for 14-26 days. We found that indicators of depressed mood were correlated with the occurrence frequency of EEG phase resetting. For most participants, the correlation coefficients swung systematically between large positive and large negative values with respect to EEG frequency; however, the frequencies at which they were maximum or minimum differed among participants. Although this study is in the pilot phase and needs further experimentation, the results are expected to lead to innovative biomarkers for early detection of depression and may contribute to a better understanding and treatment of depression.

Comprehensive Analyses of Masticatory Function in Maxillectomy Patients with Functioning Removable Prostheses: A Retrospective Cross-Sectional Study.

The aim of this retrospective cross-sectional study was to comprehensively assess masticatory function in maxillectomy patients with functioning removable prostheses. Their general and oral profiles, the measurement values of their oral functions, including masticatory function, and the history of tumor therapy were extracted from medical charts. The correlations of masticatory function with numerical data and the effects of tumor therapy-related factors on masticatory function were evaluated. In addition, a stepwise conditional logistic regression analysis was performed to identify the potential predictive factors comprehensively. The data from 55 maxillectomy patients revealed that the median value of masticatory function (138.0 mg/dL) was higher than the threshold (100.0 mg/dL) based on the concept of oral hypofunction. Moderate correlations of masticatory function with the number of remaining teeth, the number of functioning occlusal supports, and maximum occlusal force were found, as well as a weak correlation with maximum tongue pressure. These variables also showed statistically significant coefficients (p < 0.01). No significant effect of each tumor therapy-related factor on masticatory function was detected. A logistic regression analysis identified the number of functioning occlusal supports as a significant predictive factor. These results implied the crucial interactions of masticatory function with various factors and the specificities of maxillectomy patients.

Measurements of the lateral cerebellar hemispheres using near-infrared spectroscopy through comparison between autism spectrum disorder and typical development.

The cerebellum plays a vital role in cognition, communication with the cerebral cortex, and fine motor coordination. Near-infrared spectroscopy (NIRS) is a portable, less restrictive, and noninvasive functional brain imaging method that can capture brain activity during movements by measuring the relative oxyhemoglobin (oxy-Hb) concentrations in the blood. However, the feasibility of using NIRS to measure cerebellar activity requires discussion. We compared NIRS responses between areas assumed to be the cerebellum and the occipital lobe during a fine motor task (tying a bow knot) and a visual task. Our results showed that the oxy-Hb concentration increased more in the occipital lobe than in the cerebellum during the visual task (p =.034). In contrast, during the fine motor task, the oxy-Hb concentration decreased in the occipital lobe but increased significantly in the cerebellum, indicating a notable difference (p =.015). These findings suggest that we successfully captured cerebellar activity associated with processing, particularly fine motor coordination. Moreover, the observed responses did not differ between individuals with autism spectrum disorder and those with typical development. Our study demonstrates the meaningful utility of NIRS as a method for measuring cerebellar activity during movements.

A case of tricuspid valvular nonbacterial thrombotic endocarditis associated with advanced ovarian cancer.

Nonbacterial thrombotic endocarditis (NBTE) is characterized by the deposition of thrombi on the heart valves without bacteremia and predominantly affects patients with hypercoagulable state. Since the lesion of NBTE often exists in the left-sided valves, involvement of the tricuspid valve (TV) is rare. We herein report a 34-year-old woman with advanced ovarian cancer and pulmonary embolization showing NBTE on the TV. Plasma D-dimer level was markedly elevated and echocardiography showed highly mobile masses on the TV with moderate to severe regurgitation. After the initiation of heparin therapy, reduction of plasma D-dimer levels along with shrinkage of the TV vegetations was observed. However, she was forced to discontinue the heparin because its supply was interrupted in association with coronavirus disease 2019. Coupled with systemic metastasis of ovarian cancer, elevated plasma D-dimer level and exacerbation of NBTE were observed. Thereafter, she resumed subcutaneous injection of heparin, resulting in re-improvement. Learning objective: Involvement of tricuspid valve (TV) by nonbacterial thrombotic endocarditis (NBTE) is rare, especially when they are associated with advanced cancer. Our case underlines the importance of listing the NBTE as a differential diagnosis in cancer patients showing valve vegetations even in the TV.

Photobiochemical mechanisms of biomolecules relevant to germicidal ultraviolet irradiation at 222 and 254 nm.

To inactivate viruses and microorganisms, ultraviolet light in the short wavelength region is a promising candidate for mitigating the infection of disease. Germicidal mercury lamps emitting at 254 nm and KrCl excimer lamps emitting at 222 nm have sterilisation properties. In this work, wavelength dependence of the photobiochemical mechanisms was investigated with 222- and 254-nm irradiation to analyze the underlying damage mechanisms of DNA/RNA and proteins, using Escherichia coli, a protease, an oligopeptide, amino acids, plasmid DNA and nucleosides. The photorepair of damaged DNA and the "dark" reversion of the hydrates of uracil phosphoramidite coupling blocks were also investigated.

Behavioural effects of task-relevant neuromodulation by rTMS on giving-up.

Recent studies suggest that online repetitive transcranial magnetic stimulation (rTMS) can induce local entrainment of ongoing endogenous oscillatory activity during a task. This effect may impact cognitive performance, depending on the function of the oscillation. In this study, we aimed to investigate the effects of stimulation frequency and target location that are relevant to the cognitive processes of giving-up. We first investigated the correlations between the EEG oscillations and cognitive giving-up processes during problem-solving tasks (Experiment 1). We then conducted online rTMS to examine the frequency-dependent stimulation effects of rTMS on the performance of problem-solving tasks and ongoing oscillations (Experiment 2). The results of Experiment 1 suggested that the frontal theta rhythm is associated with the giving-up processes and that the frontal alpha rhythm is associated with problem-solving behaviour. Accordingly, we hypothesised that rTMS at the theta frequency would induce ongoing theta activity and accelerate the giving-up behaviour, while rTMS at the alpha frequency would induce ongoing alpha activity and slow down the giving-up behaviour in Experiment 2. The results showed that theta-frequency rTMS application induced an increase in theta amplitudes and shortened the giving-up response. Alpha-frequency rTMS application induced an increase in alpha amplitudes, but did not change giving-up responses. Considering the close resemblance between giving-up behaviour and rumination in depression, neuromodulation of cognitive giving-up processes may lead to a new intervention to treat depression by rTMS. Furthermore, this study strengthens the hypothesis that modulating task-relevant oscillations by rTMS could induce behavioural changes related to cognitive performance.

Frequency-dependent effects of EEG phase resetting on reaction time.

There is trial-to-trial variability in the reaction time to stimulus presentation. Since this variability exists even in an identical stimulus condition, it reflects the internal neural dynamics of the brain. To understand the neural dynamics that influence the reaction time, we conducted an electroencephalogram (EEG) experiment in which participants were asked to press a response button as quickly as possible when a stimulus was visually presented. Phase-locking factor analysis revealed that phase resetting in two frequency bands, which appeared 0.2 s after the stimulus presentation, characterized the reaction time. The combination of the theta band phase resetting in the left parietal region and the delta band phase resetting mainly in the posterior region was associated with the fastest reaction time, whereas delta band phase resetting without theta band phase resetting was associated with the faster reaction time. The results indicated that there were frequency-dependent effects in the relationships between the EEG phase resetting and reaction time.

Atypical cortical activation during fine motor tasks in autism spectrum disorder.

Individuals with autism spectrum disorder (ASD) often have difficulty with coordinated fine motor skills, but the degree of difficulty significantly varies from person to person. To elucidate the cause of this diversity, we monitored brain activity during fine movement tasks (tying bowknots) by near-infrared spectroscopy in 17 adults with ASD and 18 adults with typical development matched for age, gender, and intelligence quotient (IQ). We also examined the relationship between brain activation and developmental characteristics, including ASD severity, using the Autism-Spectrum Quotient and the Multi-dimensional Scale for Pervasive Developmental Disorder and Attention-Deficit/Hyperactivity Disorder. Although participants in the ASD group did not show significant clumsiness, their right prefrontal cortexes were relatively less activated, particularly in individuals with poor social skills and inattention. Our study indicates that individuals with ASD traits may use different strategies when performing fine movements; that is, they less use the brain areas responsible for processing visual image or planning behaviors.

NANOGrav Results and LIGO-Virgo Primordial Black Holes in Axionlike Curvaton Models.

We discuss a possible connection between the recent NANOGrav results and the primordial black holes (PBHs) for the LIGO-Virgo events. In particular, we focus on the axionlike curvaton model, which provides a sizable amount of PBHs and gravitational waves (GWs) induced by scalar perturbations around the NANOGrav frequency range. The inevitable non-Gaussianity of this model suppresses the induced GWs associated with PBHs for the LIGO-Virgo events to be compatible with the NANOGrav results. We show that the axionlike curvaton model can account for PBHs for the LIGO-Virgo events and the NANOGrav results simultaneously.

Genetics education program to help public health nurses improve their knowledge and enhance communities' genetic literacy: a pilot study.

BACKGROUND: As human genetics knowledge develops, public genetic literacy needs to be increased, though the educational capacity for this purpose has not yet been fully developed. Under this circumstance, the daily work of public health nurses can be viewed as an opportunity to enhance public genetic literacy. However, in Japan, there is not only a lack of public knowledge of human genomics but also a lack of public health nurses' recognition about genomic literacy. A short-term education program was implemented as a pilot study. This study aimed to examine the effectiveness of the program to support public health nurses' activity aimed at promoting health services-related genetic literacy. METHODS: The genetics education program was implemented in December 2019, in Kagoshima, Japan. Twenty-three public health nurses cooperated with the research. The program was composed of a case study on consultation, a lecture on hereditary diseases, and a discussion on the role of public health nurses. Familial hypercholesterolemia was used as the topic of the case study. We evaluated scores for cognition, affect, and psychomotor characteristics related to their learning goals before and after the program using Wilcoxon signed-rank tests. Answers in the consultation were qualitatively analyzed. RESULTS: The mean cognitive score, capturing provision of explanations of hereditary disease, was 6.3 before the program but increased significantly to 9.3 after the program (p < 0.001). For the affective score, the goal of which was deepening interest in human genetics, the mean score increased significantly from 8.5 before to 11.0 after (p < 0.001). For the psychomotor score, addressing the need for genetic consultation, the mean score increased significantly from 4.4 before to 8.1 after (p < 0.001). Prominent themes extracted from descriptions on the worksheet post training included, "providing advice and accurate information on genetic disorders" and "referral to a specialized organization." CONCLUSIONS: Our findings indicated that this education program helps public health nurses be positively involved in human genetic disorders. Thus, they may connect to their local community to provide accurate genetics knowledge and advice for health management and promoting genetic literacy.

Weather radar detection of planetary boundary layer and smoke layer top of peatland fire in Central Kalimantan, Indonesia.

During the dry period of August-October 2015, a C-band Doppler weather radar of the BMKG station in a fire-prone peatland area, Palangka Raya, detected echoes with reflectivity values between - 19 and + 34 dBZ at a height below 2-3 km and a slant range of 100 km. The MERRA-2/NASA atmospheric reanalysis database is used to obtain the vertical profiles of refractive index and equivalent potential temperature of the air. The temporal variation of the radar image is due to the tropical diurnal cycle of planetary boundary layer formation, which is consistent with the results of the database analysis. The echo images are discussed in terms of Bragg scattering of microwaves at the top of the planetary boundary layer. Weather radar monitoring of the fire smoke layer-top images has a potential feasibility to support real-time management of peatland fires.

Behavioral rhythm and EEG rhythm to determine timing deficits in attention deficit hyperactivity disorder symptoms.

One characteristic of attention deficit hyperactivity disorder (ADHD) is a timing deficit, i.e. difficulty tapping a self-selected pace and keeping the pace. The timing disorder is reported to relate to the frontal brain area. However, optimal means for evaluating this timing deficit and the corresponding neural mechanisms that accompany ADHD symptoms have not been identified. To address the issue, we required participants to tap one key of a keyboard sequentially and to maintain arbitrary tempos of their tapping intervals. We assessed ADHD symptoms using the Adult ADHD Self-Report Scale (ASRS) and evaluated brain activity via electroencephalography (EEG). Behavioral results indicated that the high ASRS group displayed a large inter-tap-interval gap (defined as the distribution of the time difference between the current tapping interval and the last one). Moreover, EEG results indicated that the work-load related brain activity (i.e. frontal beta activity) was higher in the high ASRS group. These results suggest that our tasks and analyses are useful for the evaluation of ADHD symptoms, although it was preliminary due to the small sample size and the non-patient data.

Synchronous brain networks for passive auditory perception in depressive states: A pilot study.

Recent studies have revealed a strong relationship between the default mode network (DMN) and major depression disorder (MDD). The DMN consists of several areas in the brain where activity simultaneously increases during the resting state and is suppressed during cognitive tasks (i.e., DMN suppression). Although the DMN has been evaluated in patients with MDD, it has not been studied in people with self-measured depressive symptoms without medication. Although most studies have used high-demand cognitive tasks, the relationships between MDD and passive sensory tasks remain unclear. Here, we recorded electroencephalograph (EEG) data under two sessions: a resting session and an auditory session. Moreover, we assessed depressive states with a Self-Rating Depression Scale (SDS) score. To reveal the DMN suppression mechanism in the depressive states, we used EEG time-frequency analysis. As a result, the alpha-band phase synchronization in the DMN increased during the resting session and decreased during the auditory session. The results suggest that participants in a depressive state have both an abnormal DMN connectivity and a suppressed DMN connectivity via a passive stimulus. Moreover, we were able to estimate the DMN suppression mechanism during the depressive states: (1) the beta-band phase resetting was found in the auditory and parietal areas via the auditory stimulus; (2) the beta-band transfer entropy from the auditory area to the parietal area was high as information flow among these area; and (3) the beta-band systems (information flow) were synchronized with the alpha-band DMN systems. Although the sample size was small, these results suggest that the DMN systems may already be altered during self-measured depressive symptoms like the early stages of the depressive states.

Transfer entropy for synchronized behavior estimation of interpersonal relationships in human communication: identifying leaders or followers.

A person's behavioral rhythms are synchronized spontaneously and unconsciously with those of other people, which often have positive effects, such as facilitating cooperation on tasks and promoting empathy for others. Although synchronization is induced by mutual interaction, it is unclear whether both individuals have the same influence. Is there a division of roles, in which some people are leaders and some followers? To address this, we calculated the transfer entropy (TE) of behavioral rhythms in a two-person cooperative tapping task, which provides an estimate of the direction of information propagation between two systems. We used TE to identify the causal relationship between two people (leader and follower); that is, the significant differences in the TE from one partner to another and vice versa. In this study, if there was a high TE from one individual (e.g., participant A) to the other individual (e.g., participant B), we defined participant A as the leader group and B as the follower group. First, using computer simulations, the programs which tapping intervals were almost independent with or were almost same with those of the partner programs were identified as the leader or follower, respectively, thereby confirming our hypothesis. Second, based on the results of the human experiment, we identified the leader and follower in some groups. Interestingly, the leader group showed a high systemizing quotient, which is related to communication deficits in developmental disorders such as autism. The results are consistent with participants' subjective impressions of their partners. Our methods can be used to estimate the interpersonal division of roles in complex human communications.

Contribution of left frontal-motor alpha phase synchronization to semantic inhibition in obsessive-compulsive tendencies.

Patients with obsessive-compulsive disorder attempt to suppress obsessions and/or compulsions. Although previous psychological research suggests reduced semantic inhibition in such patients, no research has explored the underlying neural mechanisms of semantic control in patients with obsessive-compulsive disorder. In addition to semantic representation, semantic control also generates task-relevant behaviors. Previous research has implicated the left frontal and posterior temporal areas in semantic control; however, no research approaches the dynamic relationships among task-relevant brain areas. To address this, we investigated the phase synchronizations among these areas using time-frequency analysis of data from an electroencephalograph, recorded during a semantic classification task. Participants were healthy patients whose obsessive-compulsive tendencies were assessed using a questionnaire. In this task, when presented with a red colored word, participants were required to classify it into categories as either plants or animals with a keypress (i.e. the classification condition). When presented with a green colored word, participants were required to read it without classification (i.e. the inhibition condition). The behavioral results showed that the semantic negative priming (i.e. the increase in reaction time to the word included in the previously inhibited category) was negatively correlated with obsessive-compulsive tendencies. Electroencephalograph results showed that the left frontal-motor alpha phase synchronization under the classification condition was significantly higher than under the inhibition condition. This phase synchronization under the inhibition condition was positively correlated with obsessive-compulsive tendencies. These results suggest that a dynamic link between the left frontal and motor areas may reflect reduced semantic inhibition in individuals with stronger obsessive-compulsive tendencies.

A novel approach for assessing neuromodulation using phase-locked information measured with TMS-EEG.

Neuromodulation therapies such as electroconvulsive therapy (ECT) are used to treat several neuropsychiatric disorders, including major depressive disorder (MDD). Recent work has highlighted the use of combined transcranial magnetic stimulation and electroencephalography (TMS-EEG) to evaluate the therapeutic effects of neuromodulation; particularly, the phase locking factor (PLF) and phase locking value (PLV) can reportedly assess neuromodulation-induced functional changes in cortical networks. To examine changes in TMS-induced PLV and PLF before and after ECT, and their relationship with depression severity in patients with MDD, TMS-EEG and the Montgomery-Åsberg Depression Rating Scale (MADRS; depression severity) were implemented before and after ECT in 10 patients with MDD. Single-pulse TMS was applied to the visual and motor areas to induce phase propagation in the visuo-motor network at rest. Functional changes were assessed using PLF and PLV data. Pre-ECT TMS-induced alpha band (9-12 Hz) PLV was negatively correlated with depression severity, and increments of post-ECT from pre-ECT TMS-induced alpha band PLV were positively correlated with the reduction in depression severity. Moreover, we found a negative correlation between pre-ECT TMS-induced PLF at TMS-destination and depression severity. Finally, differences in post-ECT TMS-induced PLF peak latencies between visual and motor areas were positively correlated with depression severity. TMS-EEG-based PLV and PLF may be used to assess the therapeutic effects of neuromodulation and depressive states, respectively. Furthermore, our results provide new insights about the neural mechanisms of ECT and depression.

Hole free phase plate tomography for materials sciences samples.

We report, for the first time, the three dimensional reconstruction (3D) of a transistor from a microprocessor chip and roughness of molecular electronic junction obtained by electron tomography with Hole Free Phase Plate (HFPP) imaging. The HFPP appears to enhance contrast between inorganic materials and also increase the visibility of interfaces between different materials. We demonstrate that the degree of enhancement varies depending on material and thickness of the samples using experimental and simulation data.

EEG dipole source localization with information criteria for multiple particle filters.

Electroencephalography (EEG) is a non-invasive brain imaging technique that describes neural electrical activation with good temporal resolution. Source localization is required for clinical and functional interpretations of EEG signals, and most commonly is achieved via the dipole model; however, the number of dipoles in the brain should be determined for a reasonably accurate interpretation. In this paper, we propose a dipole source localization (DSL) method that adaptively estimates the dipole number by using a novel information criterion. Since the particle filtering process is nonparametric, it is not clear whether conventional information criteria such as Akaike's information criterion (AIC) and Bayesian information criterion (BIC) can be applied. In the proposed method, multiple particle filters run in parallel, each of which respectively estimates the dipole locations and moments, with the assumption that the dipole number is known and fixed; at every time step, the most predictive particle filter is selected by using an information criterion tailored for particle filters. We tested the proposed information criterion first through experiments on artificial datasets; these experiments supported the hypothesis that the proposed information criterion would outperform both AIC and BIC. We then analyzed real human EEG datasets collected during an auditory short-term memory task using the proposed method. We found that the alpha-band dipoles were localized to the right and left auditory areas during the auditory short-term memory task, which is consistent with previous physiological findings. These analyses suggest the proposed information criterion can work well in both model and real-world situations.