Evanescent field-fiber loop ringdown glucose sensor.

Evanescent field-fiber loop ringdown (EF-FLRD) is a relatively new hybrid sensing technique which combines a versatile sensing mechanism with a sensitivity-enhanced ringdown detection scheme. An array of low cost, fast response, and high sensitivity biosensors based on the EF-FLRD technique can be developed. In this work, new fiber loop ringdown glucose sensors using refractive index-difference evanescent field attenuation effect as a sensing mechanism are described. The sensor head consists of either a section of partially-etched bare single mode fiber or a section of the etched fiber with glucose oxidase (GOD) immobilized on the etched fiber surface. Effects of the sensor head, with and without the immobilized GOD, on the sensor's performance are comparatively examined. The sensors' responses to standard glucose solutions and synthetic urines in different glucose concentrations ranging from 50 mg/dl to 10 g/dl are studied. The sensors, with or without the immobilized GOD, showed a linear response to glucose concentrations in the range of 100 mg/dl to 1 g/dl, but a nonlinear response in the higher glucose concentration ranging from 1 to 10 g/dl. The detection sensitivities of the sensors for the glucose solutions and artificial urine samples are 75 and 50 mg/dl respectively, and the sampling rate of the sensors is 10 to 100 Hz. Estimated theoretical detection sensitivity of the EF-FLRD glucose sensors is 10 mg/dl, which is approximately 17 times lower than the glucose renal threshold concentration.

Fiber loop ringdown sensor for potential real-time monitoring of cracks in concrete structures: an exploratory study.

A fiber loop ringdown (FLRD) concrete crack sensor is described for the first time. A bare single mode fiber (SMF), without using other optical components or chemical coatings, etc., was utilized to construct the sensor head, which was driven by a FLRD sensor system. The performance of the sensor was evaluated on concrete bars with dimensions 20 cm × 5 cm × 5 cm, made in our laboratory. Cracks were produced manually and the responses of the sensor were recorded in terms of ringdown times. The sensor demonstrated detection of the surface crack width (SCW) of 0.5 mm, which leads to a theoretical SCW detection limit of 31 µm. The sensor's response to a cracking event is near real-time (1.5 s). A large dynamic range of crack detection ranging from a few microns (µm) to a few millimeters is expected from this sensor. With the distinct features, such as simplicity, temperature independence, near real-time response, high SCW detection sensitivity, and a large dynamic range, this FLRD crack sensor appears promising for detections of cracks when embedded in concrete.

Fiber loop ringdown DNA and bacteria sensors.

We report a new type of refractive index-based biosensor using a fiber loop ringdown evanescent field (FLRD-EF) sensing scheme, in which the sensing signal is a time constant and detection sensitivity is enhanced by the multipass nature of the ringdown technique. Bulk index-based detections of three different single strand DNAs and one type of bacteria are demonstrated for the FLRD-EF sensors that utilize a partially-etched single mode fiber as the sensor head. Stepwise coating of the sensor head with poly-L-lysine and a probe DNA has enabled surface index-based label-free target DNA sensing. We expect an array of FLRD-EF biosensors to be created, which are superior to counterparts in terms of simplicity, low cost, and high sensitivity.