1.
Nucleic Acids Symp Ser (Oxf)
; (49): 289-90, 2005.
Artigo
em Inglês
| MEDLINE
| ID: mdl-17150747
RESUMO
Immortal tumor cells employ a telomere length maintenance mechanism to escape the normal limits on proliferation. We investigated whether treatment with cytosine arabinoside (AraC), whose triphosphate derivative AraCTP might partially inhibit the synthesis of C-rich telomere strands, is effective for inducing telomere shortening in human HL60 cells. Long-term treatment with 0.01 microM AraC was found to cause significant telomere lengthening, but had no marked effects on cell population doubling rates or morphology.