1.
Nucleosides Nucleotides Nucleic Acids
; 26(10-12): 1273-6, 2007.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18066767
RESUMO
We describe the preparation of two batches of a polymer support for the incorporation of folic acid into oligonucleotides. The method permits the regioselective attachment of a target nucleic acid sequence through its 3'-end to either the alpha-or gamma-carboxyl group of L-glutamic acid, respectively. The supports have been tested in solid-phase synthesis of oligonucleotide-folate conjugates for cell delivery studies.