RESUMO
Aims and tasks of the investigation of the DNA contents in tumour cells are discussed. It is supposed that DNA aneuploidia is a specific sign of malignant cells. Such supposition permits solving the problem of quantitative identification of malignant cells in the complex cell populations and determination of their quantity. Certain conditions necessary for solving this problem are considered.
Assuntos
Aneuploidia , DNA de Neoplasias/análise , Neoplasias/genética , Animais , Aberrações Cromossômicas , DNA de Neoplasias/genética , Citometria de Fluxo , Humanos , Camundongos , Neoplasias/patologiaRESUMO
It is shown that in the course of a cytological investigation it was possible not only to diagnose lymphogranulomatosis but in the overwhelming majority of cases to determine a morphological variant of the disease in accordance with Lukes et al. classification. Cytological pictures of the three histological variants of lymphogranulomatosis are described: mixed-cellular, reticular and nodular sclerosis. Cytological criteria for diagnosis of nodular sclerosis are identified.