RESUMO
Different neuronal responses to electrical stimuli under the effect of proteolytic enzymes, were shown. Different mechanisms of neuronal responses to stimuli were shown to depend on disturbances in neuroglial interrelationships. Two forms of the firing rate transformation depending on the type of stimulation, were described.
Assuntos
Neurônios/efeitos dos fármacos , Peptídeo Hidrolases/farmacologia , Animais , Estimulação Elétrica/métodos , Eletrofisiologia , Sanguessugas , Neurônios/fisiologiaRESUMO
As it has been demonstrated in the giant (Retzius') neuron of the leech (Hirudo medicinalis), at the synaptic activation for 5 sec. and 10 min., ultrastructural changes in the neuron are accompanied with an increasing number of Ca++ ions in hyaloplasm, mitochondria and cytosomes. After activation, the ultrastructural changes increase, and the number of Ca++ ions returns to the initial level. A suggestion is made on a trigger function of Ca++ ions when the neuronal ultrastructure changes under conditions of the synaptic activation.