RESUMO
A case--control study was conducted to evaluate the relationship between C481T and G590A polymorphisms of arylamine-N-acetyltransferase 2 and predisposition to atopic dermatitis in children. Double heterozygote 481C/T and 590G/A in girls is a factor of resistance to atopic dermatitis, especially in the absence of smoking-related effects.
Assuntos
Arilamina N-Acetiltransferase/genética , Dermatite Atópica/genética , Polimorfismo Genético , Adolescente , Alelos , Substituição de Aminoácidos , Estudos de Casos e Controles , Criança , Pré-Escolar , DNA/sangue , DNA/genética , Dermatite Atópica/diagnóstico , Dermatite Atópica/epidemiologia , Feminino , Frequência do Gene , Predisposição Genética para Doença , Glicina/metabolismo , Heterozigoto , Humanos , Incidência , Lactente , Masculino , Reação em Cadeia da Polimerase , Fatores de Risco , Fatores SexuaisRESUMO
We studied the association of GSTM1 and GSTT1 and GSTP1 Ile105-Val105 polymorphism with the duration of intoxication, polyorgan failure, and severity of drug poisoning in children. The combination of GSTM1 and GSTT1 zero genotypes is a favorable sign for the duration of intoxication and severity of the disease.
Assuntos
Glutationa Transferase/genética , Intoxicação/genética , Polimorfismo Genético , Criança , Intervalos de Confiança , Humanos , Razão de Chances , Intoxicação/enzimologiaRESUMO
The 6beta-hydroxycortisol/cortisol ratio was measured in 52 children aging 1.1-14.0 years. The maximum increment in this ratio occurred in the age interval of 1.1-2.0 years. During this period, the regression coefficients in the linear (r=0.57; p=0.044) and nonlinear logarithmic models (r=0.56; p=0.049) were similar. At the age of 10-14 years, the examined ratio attained 19.17+/-17.79.
Assuntos
Sistema Enzimático do Citocromo P-450/metabolismo , Adolescente , Criança , Pré-Escolar , Humanos , Hidrocortisona/análogos & derivados , Hidrocortisona/urina , LactenteRESUMO
We determined the prevalence of GSTP1-Ile105 and GSTP1-Val105 alleles in patients with bronchial asthma and atopic dermatitis and healthy children of 2 groups (randomized and nonatopic control). The GSTP1-Ile105/Val105 genotype determines the resistance to atopic dermatitis (odds ratio=0.51; 95% confidence interval: 0.28-0.92; p=0.023). However, both homozygotes are at high risk of developing atopic dermatitis (near-significant differences).
Assuntos
Asma/genética , Dermatite Atópica/genética , Glutationa Transferase/genética , Polimorfismo Genético , Alelos , Criança , Feminino , Genótipo , Homozigoto , Humanos , Isoleucina/química , Masculino , Razão de Chances , Risco , Federação Russa , Valina/química , Xenobióticos/farmacologiaRESUMO
The frequency of individual genotypes GSTM1, GSTT1, and GSTP1 and haplotypes was determined in patients with atopic dermatitis and healthy children. The actual frequency of some haplotypes was far below the theoretical value. Some haplotypes were associated with predisposition and resistance to atopic dermatitis.
Assuntos
Dermatite Atópica/genética , Predisposição Genética para Doença , Genótipo , Glutationa Transferase , Isoenzimas , Adolescente , Alelos , Estudos de Casos e Controles , Criança , Pré-Escolar , Dermatite Atópica/epidemiologia , Feminino , Frequência do Gene , Glutationa S-Transferase pi , Haplótipos , Humanos , Lactente , Masculino , Razão de Chances , Polimorfismo Genético , Federação Russa/epidemiologiaRESUMO
A spectrophotometric micromethod for determination of theophylline in the blood is proposed. Theophylline pharmacokinetics was studied by the method in 71 children with bronchial asthma. Doses and the number of administrations were selected individually for 45 patients under control of blood plasma theophylline concentration. Good clinical results were obtained.
