1.
2.
Biol Psychiatry
; 79(10): e75-e77, 2016 05 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-27130853
3.
Neurosurg Clin N Am
; 25(4): 671-92, 2014 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-25240656
RESUMO
For over half a century, neurosurgeons have attempted to treat pain from a diversity of causes using acute and chronic intracranial stimulation. Targets of stimulation have included the sensory thalamus, periventricular and periaqueductal gray, the septum, the internal capsule, the motor cortex, posterior hypothalamus, and more recently, the anterior cingulate cortex. The current work focuses on presenting and evaluating the evidence for the efficacy of these targets in a historical context while also highlighting the major challenges to having a double-blind placebo-controlled clinical trial. Considerations for pain research in general and use of intracranial targets specifically are included.