The potential role of dynamic thermal analysis in breast cancer detection.

BACKGROUND: It is presently well accepted that the breast exhibits a circadian rhythm reflective of its physiology. There is increasing evidence that rhythms associated with malignant cells proliferation are largely non-circadian. Cancer development appears to generate its own thermal signatures and the complexity of these signatures may be a reflection of its degree of development. The limitations of mammography as a screening modality especially in young women with dense breasts necessitated the development of novel and more effective screening strategies with a high sensitivity and specificity. The aim of this prospective study was to evaluate the feasibility of dynamic thermal analysis (DTA) as a potential breast cancer screening tool. METHODS: 173 women undergoing mammography as part of clinical assessment of their breast symptoms were recruited prior to having a biopsy. Thermal data from the breast surface were collected every five minutes for a period of 48 hours using eight thermal sensors placed on each breast surface [First Warning System (FWS), Lifeline Biotechnologies, Florida, USA]. Thermal data were recorded by microprocessors during the test period and analysed using specially developed statistical software. Temperature points from each contra-lateral sensor are plotted against each other to form a thermal motion picture of a lesion's physiological activity. DTA interpretations [positive (abnormal thermal signature) and negative (normal thermal signature)] were compared with mammography and final histology findings. RESULTS: 118 (68%) of participating patients, were found to have breast cancer on final histology. Mammography was diagnostic of malignancy (M5) in 55 (47%), indeterminate (M3, M4) in 54 (46%) and normal/benign (M1, M2) in 9 (8%) patients. DTA data was available on 160 (92.5%) participants. Using our initial algorithm, DTA was interpreted as positive in 113 patients and negative in 47 patients. Abnormal thermal signatures were found in 76 (72%) out of 105 breast cancer patients and 37 of the 55 benign cases. Then we developed a new algorithm using multiple-layer perception and SoftMax output artificial neural networks (ANN) on a subgroup (n = 38) of recorded files. The sensitivity improved to 76% (16/21) and false positives decreased to 26% (7/27) CONCLUSION: DTA of the breast is a feasible, non invasive approach that seems to be sensitive for the detection of breast cancer. However, the test has a limited specificity that can be improved further using ANN. Prospective multi-centre trials are required to validate this promising modality as an adjunct to screening mammography especially in young women with dense breasts.

Medical tourism and reproductive outsourcing: the dawning of a new paradigm for healthcare.

Medical tourism, a term that also can be used to describe medical outsourcing, is characterized by travel away from one's home region to procure treatment in another. It may take one of two forms: obligatory or elective. The former occurs when necessary treatments are unavailable or illegal in the place of origin. The latter includes elective and medically indicated procedures that, although available at the place of origin, may be delivered more quickly or in a more cost-effective manner in another location. Reproductive outsourcing is a special form of medical tourism that has quickly become an important area of present-day medicine because the changes of the last four decades have left all but the most advanced fertility centers breathless as they try to adjust their treatment protocols in effective and ethical manners. Legal and policy limitations have created a global environment where, in a rising number of instances, individuals and couples must travel elsewhere to procure fertility procedures that are unavailable back home. With low cost airfares to and from America, a growing number of "medical cartographers" have set out to map which places are the "best" (in terms of cost, effectiveness and timeliness), for what procedures, and for whom. On the other hand, physicians, legal experts and policy makers have only begun to shape how government and health care agencies should formally guide or regulate medical tourism. In doing so, a number of factors may challenge the limits of ethics, policy and legality in this most important trend in modern medicine.

Circadian rhythm chaos: a new breast cancer marker.

The most disappointing aspect of breast cancer treatment as a public health issue has been the failure of screening to improve mortality figures. Since treatment of late-stage cancer has indeed advanced, mortality can only be decreased by improving the rate of early diagnosis. From the mid-1950s to the mid-1970s, it was expected that thermography would hold the key to breast cancer detection, as surface temperature increases overlying malignant tumors had been demonstrated by thermographic imaging. Unfortunately, detection of the 1-3 degrees C thermal differences failed to bear out its promise in early identification of cancer. In the intervening two-and-a-half decades, three new factors have emerged: it is now apparent that breast cancer has a lengthy genesis; a long-established tumor-even one of a certain minimum size-induces increased arterial/capillary vascularity in its vicinity; and thermal variations that characterize tissue metabolism are circadian ("about 24 hours") in periodicity. This paper reviews the evidence for a connection between disturbances of circadian rhythms and breast cancer. Furthermore, a scheme is proposed in which circadian rhythm "chaos" is taken as a signal of high risk for breast cancer even in the absence of mammographic evidence of neoplasm or a palpable tumor. Recent studies along this line suggest that an abnormal thermal sign, in the light of our present knowledge of breast cancer, is ten times as important an indication as is family history data.

Maternal race/ethnicity and twinning rates in the United States, 1989-1991.

OBJECTIVE: To utilize United States birth certificate data (years 1989-1991) to examine the effects of race/ethnicity on twinning rates. STUDY DESIGN: We used a database of birth certificate data for the United States (years 1989-1991) available on CD-ROM from the United States National Center for Health Statistics. This linked birth/infant death data set included a total of 12,036,234 birth records, of which 279,073 were twins. Excluded from the analysis were 15,086 twin birth records (5.4%) based upon previously described exclusion criteria. Statistical analysis included a series of univariate analyses to determine the rates of twinning between different racial/ethnic groups correlated with maternal age, education, marital status and place of birth. Comparisons were analyzed using the chi 2 test, with significance at P < .05. RESULTS: The overall twinning rate was 2.26%, with the lowest rate observed in the group denoted non-Hispanic other (1.67%) and highest among non-Hispanic blacks (2.69%). Twinning rates within various groups representing Hispanics ranged from 1.76% to 2.08%. The twinning rate was significantly higher among U.S.-born as compared to non-U.S.-born women (2.34% vs. 1.88%, P < .005) except for Puerto Ricans, Cubans and Central/South Americans, for whom the reverse was true. Women aged 35-39 had the highest twinning rate (3.05%), whereas women aged 15-19 had the lowest; that trend persisted in all racial/ethnic groups. The study showed a nonsignificant relationship between marital status or education and twinning rate. CONCLUSION: Race/ethnicity studies can be useful in designing programs that may maximize health outcomes of twins in a racially diverse population.

A critical assessment of generic substitution for the obstetrician-gynecologist.

In the past decade, generic drugs have increased in market share severalfold. There are drugs used in obstetrics/gynecology that are of concern with regard to generic substitution, because they are believed to be well tested and essentially not dangerous. The present review is mainly of the use of generics in oral contraception and assisted reproduction. It seeks to answer the question, whether cost advantages, great or slight, offered by the generics are well worth the attendant need for increased vigilance by clinicians and, possibly, taking care of increased side effects or even mishaps resulting from lack of effectiveness (or excessive "effectiveness"). The discussion is based on the concepts of bioavailability and therapeutic equivalence.

Multiple gestation: reflections on epidemiology, causes, and consequences.

Multiple births (of all orders) increased in epidemic proportions in the years 1971-1997. Twins increased 53%, 32%, 31%, and 83% in white, Afro-American, Native American and Mexican American women, respectively. Triplet, quadruplet, and quintuplet+ births increased >400%, >1,100%, and >500%, respectively, in the same years. The principal causes of these changes are related to the increasing age of the maternal cohort and an increasing incidence of fertility-inhibiting diseases and conditions in association with advancing maternal age. Major immediate consequences of these changes include disproportionately large numbers of infants born at <33 weeks' gestation (1.7% for singletons vs. 41.2% for triplets) and at <1,500 g birth weight (1.1% for singletons vs. 31.9% for triplets). Additional short-term consequences include an almost 2,000% increase in infant deaths (per 1,000 live births) among triplets compared with singletons (190.4 vs. 11.2). Long-term risks include a 300% increase in the relative risk of handicap in triplets compared with singletons (2.9 vs. 1.0), and a 650% increase in the rate of cerebral palsy per 1,000 live births in triplets compared with singletons (26.6 vs. 1.6). Peripartum costs relate to prematurity rather than plurality, as do lifetime survivorship costs, which relate to morbidities and subsequent health-related problems.

Doppler sonographic demonstration of arterio-venous anastomosis in monochorionic twin gestation.

Arterio-venous connections, which are known to occur in monochorionic twin placentae and are a mechanism for the development of twin-to-twin transfusion syndrome, can be demonstrated in utero by means of targeted sonography with the use of spectral and color flow Doppler techniques.

Vaginal infection: prophylaxis and perinatal outcome--a review of the literature.

Vaginal discharge is the symptom that most often prompts a woman to consult a physician in order to determine the presence of an infection. However, much vaginal infection, particularly bacterial vaginosis, is nearly asymptomatic. In all cases, diagnosis is based on evaluation of the vaginal ecosystem and demonstration of the presence of the suspected microorganism. Besides bacteria, fungi (Candida) and protozoans (Trichomonas) are very common pathogens and produce characteristic findings. When present during pregnancy, these infections have been linked to low birth weight and obstetric disorders. There is a great need for a full understanding of the connection between what appears to be "normal" discharge in pregnancy and important adverse perinatal outcomes.

Conditions predisposing to maternal mortality in twins and singletons, US birth cohort 1989.

Twin pregnancy is one of the most important conditions associated with increased perinatal mortality and morbidity. The consequences of twin pregnancy on the mother have not been explored in great detail. The aim of this study was to analyze the population-based data from the United States and delineate the various conditions of twin pregnancies which predispose to maternal mortality. Results of this study show that multiple pregnancy is strongly associated with maternal mortality and requires further analysis in order to prepare appropriate therapeutic and prophylactic protocols.

Zygosity of twins: is it time for a new terminology?

The term zygosity reflects the origin of twins--when twins are monozygotic, they are derived from a single fertilized ovum; when twins are dizygotic--the come from two fertilized ova. Zygosity assessment seemed straightforward 50 years ago. Currently, as more information and more technology becomes available, zygosity testing becomes a real problem. It is important to realize the importance of correct zygosity testing not only in the antepartum care of the pregnant mother, but more importantly--during the whole lifetime of twin individuals. This paper discusses revolving around zygosity, methods of assessment, their limitations and proposes new terminology which incorporates the recent knowledge about early human development.

[Peculiarities of multiple pregnancy: epidemiology]. / Osobliwosci ciazy mnogiej: epidemiologia.

The epidemiology of multiple pregnancy is complex and depends on various factors including age, race, genetic and environmental factors, season of conception and, more recently, iatrogenic factors. In recent years, twinning rate increased dramatically especially in countries where ovulation induction and assisted reproductive technologies are widely used. Multiple pregnancies are most frequent in Nigeria where majority of them are dizygotic. The lowest frequency of twinning is observed in Japan where almost 70% of multiples are monozygotic. This paper discusses genetic, environmental and sociocultural factors which are related to the "epidemic" of multiples.

[Peculiarities of multiple pregnancy: embryology]. / Osobliwosci ciazy mnogiej: embriologia.

Multiple pregnancies are not physiologic in humans and the understanding of the pathogenesis of this phenomenon is not fully established. Embriology of multiple pregnancy has been extensively investigated and this paper presents the phases of embrional development of monozygotic and dizygotic twins.

[Peculiarities of multiple pregnancy: diagnosis]. / Osobliwosci ciazy mnogiej: diagnostyka.

Before ultrasound was aggressively introduced into everyday obstetrical practice, diagnosis, prophylaxis and active pre- and perinatal management were at best inadequate, but more often nonexistent. Twin pregnancies were complicated by high perinatal morbidity and mortality. The use of classical radiography was limited due to proven teratogenic and carcinogenic properties. Introduction of ultrasound dramatically changed the obstetrician's approach to twin pregnancy management. This paper discusses in detail the recent advances in ultrasound diagnosis of twin pregnancy.

[Peculiarities of multiple pregnancy: complications]. / Osobliwosci ciazy mnogiej: powiklania.

Multiple pregnancies are considered high risk. This qualification is associated with the multitude of conditions which are known to complicated these pregnancies. Early diagnosis of these complications is the fundamental element of clinical managements. In numerous cases therapeutic protocols are widely known and in many others intensive monitoring and appropriate management may save the fetus from early and late complications. This paper will discuss the most common prenatal and perinatal complications associated with multiple pregnancies as well as the most widely accepted therapeutic protocols.

Projections of population-based twinning rates through the year 2100.

OBJECTIVE: To present the first compilation of population-based twinning rates published after the year 1990 and to project population-based twinning rates through the year 2100. STUDY DESIGN: We searched the Internet-based MEDLINE database for articles published after 1990 in which population-based twinning rates were described. We used population-based data from national statistical authorities from Australia, Austria, Canada, Finland, Hong Kong, Israel, Japan, Norway, Singapore and Sweden, published by Y. Imaizumi in a recent article. U.S. figures were based on data from the National Center for Health Statistics. Annual growth rates of twinning were calculated and graphed, making the assumption that these rates would remain constant throughout the next century. RESULTS: Our report presents the most recent population-based twinning rates. When projected through the year 2015, twinning rates reach figures that could best be described as derived from a Jules Verne novel: Sweden, in this model, would have four times more twin than singleton births. CONCLUSION: We strongly suggest that physicians reexamine their patterns of prescribing ovulation-inducing agents, which carry a greatly increased risk of multiple pregnancy.

Generics: what's in a name?

Historically, the most common intervention performed by physicians has been the writing of a prescription. Often the prescription was a combination of active agents and an inactive base. This art is no longer practiced in the United States. Currently, most prescriptions are written for specific "drugs." As the prescription is being written, the physician must decide to administer a brand-name or a generic equivalent. Generics are a class of medications prescribed for reasons of economy, and the physician and the patient expect that the therapeutic effect will be exactly the same as for the brand-name. Bioequivalence of specific agents can be assessed using the FDA's Orange Book. In addition to bioequivalence, many other scientific, ethical, and economic issues should be considered before a decision is made. Prescribing vigilance is necessary, because in many instances available information is often controlling or insufficient to support rational decisions. Brand-names, rather than generics, should be selected when the therapeutic index is narrow or if the likelihood of generic switching is high. The paper will discuss all aspects of the subject.