RESUMO
As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the Toxicological Profile for Benzene. The primary purpose of this article is to provide public health officials, physicians, toxicologists, and other interested individuals and groups with an overall perspective on the toxicology of benzene. It contains descriptions and evaluations of toxicological studies and epidemiological investigations and provides conclusions, where possible, on the relevance of toxicity and toxicokinetic data to public health.
Assuntos
Benzeno/toxicidade , Carcinógenos Ambientais/toxicidade , Exposição Ambiental/efeitos adversos , Saúde Pública , Animais , Animais de Laboratório , Monitoramento Ambiental , Feminino , Humanos , Masculino , Sistema de Registros , Estados Unidos , United States Dept. of Health and Human ServicesRESUMO
As part of its mandate, the Agency for Toxic Substances and Disease Registry (ATSDR) prepares toxicological profiles on hazardous chemicals found at Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) National Priorities List (NPL) sites that have the greatest public health impact. These profiles comprehensively summarize toxicological and environmental information. This article constitutes the release of portions of the toxicological profile for benzene. The primary purpose of this article is to provide interested individuals with environmental information on benzene that includes production data, environmental fate, potential for human exposure, analytical methods, and a listing of regulations and advisories.
Assuntos
Benzeno/toxicidade , Carcinógenos Ambientais/toxicidade , Exposição Ambiental/efeitos adversos , Monitoramento Ambiental , Saúde Pública , Benzeno/análise , Carcinógenos Ambientais/análise , Indústria Química , Exposição Ambiental/legislação & jurisprudência , Feminino , Humanos , Masculino , Sistema de Registros , Medição de Risco , Estados Unidos , United States Dept. of Health and Human ServicesAssuntos
Neoplasias/etiologia , Revisão por Pares , Bifenilos Policlorados/efeitos adversos , Sistema de Registros , Medição de Risco , United States Dept. of Health and Human Services , Humanos , Serviços de Informação , Neoplasias/epidemiologia , Bifenilos Policlorados/classificação , Controle de Qualidade , Estados UnidosRESUMO
Some vaccines contain aluminum adjuvants to enhance the immunological response, and it has been postulated that this aluminum could contribute to adverse health effects, especially in children who receive a vaccination series starting at birth. The pharmacokinetic properties and end-point toxicities of aluminum are presented. In assessing the relevance of dietary and medical aluminum exposure to public health, we estimated infant body burdens during the first year of life for breast milk and formula diets and for a standard vaccination schedule. We then compared those body burdens with that expected for intake at a level considered safe for intermediate-duration exposure. The methodology blends intake values and uptake fractions with an aluminum retention function derived from a human injection study using radioactive 26Al. The calculated body burden of aluminum from vaccinations exceeds that from dietary sources, however, it is below the minimal risk level equivalent curve after the brief period following injection.
