RESUMO
The objectives of the present study were to assess the impact of lactation on the folate status of adolescents and determine the effect of ingestion of a low-dose postpartum (PP) folic acid supplement on maternal folate and zinc status and milk composition. Pregnant adolescents (aged 14-19 y; n = 71) were recruited; those who initiated breast-feeding on delivery were randomly assigned to a folic acid supplement lactating (SL; 300 micrograms/d, n = 14) group or to a placebo lactating (PL; n = 15) group. Subjects who initiated formula feeding were given a placebo (FF; n = 18). Dietary intakes (two 24-h recalls) were recorded and blood and milk samples were collected at 4, 8, and 12 wk PP. Of the adolescents, 71%, 48%, 67%, and 60% had folate, iron, vitamin B-12, and zinc intakes, respectively, below their predicted requirements. Despite this, most blood indexes were within normal ranges, probably reflecting the subjects' use of supplements during pregnancy. Red blood cell (r = -0.49, P < 0.05) and plasma (r = -0.42, P = 0.08) folate concentrations were negatively correlated with milk zinc concentrations. Mean red blood cell folate content declined between 4 and 12 wk PP among PL (31%) and FF (34%) subjects (P < 0.05) but not among SL subjects. Hence, 300 micrograms folic acid/d was sufficient to prevent a decline in blood folate values of these adolescents PP.
