RESUMO
Four siblings with Papillon-Lefèvre syndrome (3 boys and 1 girl), aged 8 to 12 at time of first diagnosis in 1978 are reported. These four patients represent the second largest sibship reported in the literature, and the only familial cases treated with etretinate for 6 years with an additional 3 1/2 year follow-up evaluation. No long-term side effects of etretinate were found in the children. All four patients are the product of a second cousin marriage; all demonstrate the B5 locus on HLA typing.
Assuntos
Etretinato/uso terapêutico , Doença de Papillon-Lefevre/tratamento farmacológico , Criança , Etretinato/efeitos adversos , Feminino , Seguimentos , Humanos , Ceratodermia Palmar e Plantar , Masculino , Doença de Papillon-Lefevre/genéticaRESUMO
In major American textbooks of dermatology and medicine the use of intralesional sodium stibogluconate (Pentostam) in the treatment of cutaneous leishmaniasis is not mentioned. In this brief informal communication I have summarized personal experience with this effective treatment modality.
Assuntos
Gluconato de Antimônio e Sódio/uso terapêutico , Gluconatos/uso terapêutico , Leishmaniose/tratamento farmacológico , Adolescente , Adulto , Idoso , Gluconato de Antimônio e Sódio/administração & dosagem , Criança , Pré-Escolar , Humanos , Lactente , Injeções , Pessoa de Meia-IdadeRESUMO
Oral tetracycline eliminated the histochemical staining for nonspecific esterase in human sebaceous glands after two weeks of administration. This evidence offers further support for the hypothesis that the clinical benefits of tetracycline result from suppression of follicular esterase-lipases, probably those from C. acnes.
