RESUMO
Gastrin-releasing peptide immunoreactivity has been seen in functioning endocrine tumours which are recognized as a major cause of secretory diarrhea. The authors describe a case of a 52-year-old woman who had secretory diarrhea (5 L/d) with markedly elevated gastrin-releasing peptide levels associated with islet cell hyperplasia. No tumour could be identified. The diarrhea was controlled by somatostatin analogue.
Assuntos
Diarreia/tratamento farmacológico , Ilhotas Pancreáticas/patologia , Peptídeos/sangue , Somatostatina/análogos & derivados , Diarreia/sangue , Diarreia/etiologia , Feminino , Peptídeo Liberador de Gastrina , Humanos , Hiperplasia , Injeções Subcutâneas , Pessoa de Meia-Idade , Biossíntese Peptídica , Somatostatina/administração & dosagem , Somatostatina/uso terapêuticoRESUMO
To examine possible sources of Campylobacter pylori and to determine the routes by which it is transmitted to the human stomach, samples of dental plaque and saliva from 71 patients undergoing endoscopy in addition to stomach biopsies were collected and cultured on selective noninhibitory Skirrow medium. A total of 29 (40.8%) of the stomach biopsies yielded C. pylori. None of the saliva samples and only one of the dental plaque samples was found positive for C. pylori, and thus neither saliva nor dental plaque could be implicated as a significant reservoir of this organism.
Assuntos
Campylobacter/isolamento & purificação , Placa Dentária/microbiologia , Saliva/microbiologia , Estômago/microbiologia , Biópsia , Gastroscopia , HumanosRESUMO
Antral biopsy specimens from patients with acid peptic disease were cultured in parallel on Skirrow medium (SM) and sheep blood agar (SBA) for Campylobacter pylori. In institution 1, 23 of 88 (26.1%) endoscopies were positive on SBA compared with 37 of 88 (42.0%) on SM (P = 0.0001). In institution 2, 29 of 49 (59.2%) endoscopies were positive for C. pylori on SBA and 27 of 49 (55.1%) were positive on SM (P = 0.50). The addition of SM optimizes the recovery of C. pylori from antral biopsy specimens.
Assuntos
Campylobacter/isolamento & purificação , Estômago/microbiologia , Biópsia , Meios de Cultura , Gastroscopia , Humanos , Antro Pilórico/microbiologia , Antro Pilórico/patologia , Estômago/patologiaAssuntos
Hepatite B/complicações , Hepatite D/complicações , Hepatite Viral Humana/patologia , Complicações Infecciosas na Gravidez , Doença Aguda , Adolescente , Anticorpos Antivirais/análise , Feminino , Hepatite B/imunologia , Hepatite B/patologia , Anticorpos Anti-Hepatite B/análise , Antígenos de Superfície da Hepatite B/análise , Hepatite D/imunologia , Hepatite D/patologia , Vírus Delta da Hepatite/imunologia , Hepatite Viral Humana/imunologia , Humanos , Técnicas Imunológicas , Fígado/patologia , Gravidez , Transtornos Relacionados ao Uso de Substâncias/complicaçõesRESUMO
Campylobacter pyloridis has been associated with acid-peptic disease in centres outside Canada. The authors conducted a pilot study to see if this association existed in Toronto. Patients in whom esophagogastroscopy was indicated on clinical grounds were arbitrarily selected for determination of the presence of C. pyloridis. Included in the study were 100 patients who underwent 105 endoscopies. In 75 patients (80 endoscopies) there was some form of acid-peptic disease (inflammation or ulceration of stomach or duodenum). Of those with acid-peptic disease, 34% had C. pyloridis compared with 4% among patients without acid-peptic disease (p less than 0.01). Men with acid-peptic disease were more likely to harbour C. pyloridis than women (48% versus 16%, p less than 0.01). The organisms were curved gram-negative rods that appeared as small colonies after 4 days of incubation under microaerobic conditions. They were strongly urease positive. There was considerable heterogeneity of endoscopic diagnoses. Future clinical studies of C. pyloridis need careful endoscopic and histologic classification.
