RESUMO
Rosai-Dorfman disease (RDD), also known as sinus histiocytosis with massive lymphadenopathy (SHML), is a systemic disease involving nodal and extranodal tissues. We report a 48-year-old female with recurrent nasal obstruction due to polypoidal masses involving the nasal sinuses, turbinates and septum bilaterally, and lumps in the right infra-orbital region and region of the right lacrimal sac. A 4 cm right upper neck mass was also noted, which was initially diagnosed as histiocytic lymphoma. Histopathology of the nasal and infraorbital lesions revealed fibro-inflammatory masses containing histiocytic cells with large vesicular nuclei and abundant foamy cytoplasm exhibiting emperipolesis and lymphophagocytosis, admixed with scattered plasma cells and lymphocytes. These histiocytes revealed immunohistochemical positivity for S-100 protein and CD68, but were negative for CDla. The findings supported a diagnosis of RDD. This report serves to remind pathologists and clinicians of the extranodal manifestations of RDD and its potential confusion with lymphomas.
Assuntos
Histiocitose Sinusal/diagnóstico , Linfoma Difuso de Grandes Células B/diagnóstico , Obstrução Nasal/etiologia , Erros de Diagnóstico , Feminino , Histiocitose Sinusal/complicações , Histiocitose Sinusal/metabolismo , Humanos , Imuno-Histoquímica , Pessoa de Meia-IdadeRESUMO
A 31 years old Chinese male with acquired immunodeficiency syndrome (AIDS) presented with concurrent mycobacterial infection and a synchronous non-Hodgkin's lymphoma of the nose. The diagnoses were made over a period of two months. Treatment for the mycobacterial infection was administered but he succumbed to the disease shortly after the diagnosis of NHL was established. This was an unusual case where two pathologies occurred in the same site in a patient with AIDS.
Assuntos
Linfoma Relacionado a AIDS/complicações , Infecções por Mycobacterium/complicações , Neoplasias Nasais/complicações , Adulto , Diagnóstico Diferencial , Evolução Fatal , Humanos , Linfoma Relacionado a AIDS/diagnóstico , Masculino , Infecções por Mycobacterium/diagnóstico , Neoplasias Nasais/diagnósticoRESUMO
Carcinoma of the tongue remain one of the greatest management challenges for the head and neck surgeon because of the adverse effects of treatment on oral and pharyngeal function. In early carcinoma of the base of tongue however, the prognosis is encouraging and function of swallowing and speech is preserved despite surgery. Suprahyoid pharyngotomy is one of the surgical approaches advocated for resection of base of tongue tumours with primary anastomosis.
