The effect of inherent and incidental constraints on bimanual force control in simulated Martian gravity.

The ability to coordinate actions between the limbs is important for many operationally relevant tasks associated with space exploration. A future milestone in space exploration is sending humans to Mars. Therefore, an experiment was designed to examine the influence of inherent and incidental constraints on the stability characteristics associated with the bimanual control of force in simulated Martian gravity. A head-up tilt (HUT)/head-down tilt (HDT) paradigm was used to simulate gravity on Mars (22.3° HUT). Right limb dominant participants (N = 11) were required to rhythmically coordinate patterns of isometric forces in 1:1 in-phase and 1:2 multifrequency patterns by exerting force with their right and left limbs. Lissajous displays were provided to guide task performance. Participants performed 14 twenty-second practice trials at 90° HUT (Earth). Following a 30-min rest period, participants performed 2 test trials for each coordination pattern in both Earth and Mars conditions. Performance during the test trials were compared. Results indicated very effective temporal performance of the goal coordination tasks in both gravity conditions. However, results indicated differences associated with the production of force between Earth and Mars. In general, participants produced less force in simulated Martian gravity than in the Earth condition. In addition, force production was more harmonic in Martian gravity than Earth gravity for both limbs, indicating that less force distortions (adjustments, hesitations, and/or perturbations) occurred in the Mars condition than in the Earth condition. The force coherence analysis indicated significantly higher coherence in the 1:1 task than in the 1:2 task for all force frequency bands, with the highest level of coherence in the 1-4 Hz frequency band for both gravity conditions. High coherence in the 1-4 Hz frequency band is associated with a common neural drive that activates the two arms simultaneously and is consistent with the requirements of the two tasks. The results also support the notion that neural crosstalk stabilizes the performance of the 1:1 in-phase task. In addition, significantly higher coherence in the 8-12 Hz frequency bands were observed for the Earth condition than the Mars condition. Force coherence in the 8-12 Hz bands is associated with the processing of sensorimotor information, suggesting that participants were better at integrating visual, proprioceptive, and/or tactile feedback in Earth than for the Mars condition. Overall, the results indicate less neural interference in Martian gravity; however, participants appear to be more effective at using the Lissajous displays to guide performance under Earth's gravity.

The influence of distal and proximal muscle activation on neural crosstalk.

Previous research has indicated that neural crosstalk is asymmetric, with the dominant effector exerting a stronger influence on the non-dominant effector than vice versa. Recently, it has been hypothesized that this influence is more substantial for proximal than distal effectors. The current investigation was designed to determine the effects of distal ((First Dorsal Interosseous (FDI)) and proximal (triceps brachii (TBI)) muscle activation on neural crosstalk. Twelve right-limb dominant participants (mean age = 21.9) were required to rhythmically coordinate a 1:2 pattern of isometric force guided by Lissajous displays. Participants performed 10, 30 s trials with both distal and proximal effectors. Coherence between the two effector groups were calculated using EMG-EMG wavelet coherence. The results indicated that participants could effectively coordinate the goal coordination pattern regardless of the effectors used. However, spatiotemporal performance was more accurate when performing the task with distal than proximal effectors. Force distortion, quantified by harmonicity, indicated that more perturbations occurred in the non-dominant effector than in the dominant effector. The results also indicated significantly lower harmonicity for the non-dominant proximal effector compared to the distal effectors. The current results support the notion that neural crosstalk is asymmetric in nature and is greater for proximal than distal effectors. Additionally, the EMG-EMG coherence results indicated significant neural crosstalk was occurring in the Alpha bands (5-13 Hz), with higher values observed in the proximal condition. Significant coherence in the Alpha bands suggest that the influence of neural crosstalk is occurring at a subcortical level.

Bayesian integration during sensorimotor estimation in elite athletes.

An experiment was designed to determine the effects of sensory uncertainty on sensorimotor estimation in elite athletes compared to non-athletes. Nineteen elite athletes and 16 non-athletes were required to estimate when and where a cursor arrived at a target location. The cursor position was displayed through its entire trajectory in the certain condition while only briefly in the uncertain condition. Accuracy and variability in time and spatial domains were calculated. A Bayesian analysis using subsets of subjects' total spatial variance was also performed. The results indicated that athletes and non-athletes used estimation strategies consistent with Bayesian integration. The results also showed a decrease in variability for spatial performance for both groups during the uncertain condition compared to the certain condition, especially when the cursor location was further away from the prior mean. This decrease in variability was significantly greater for non-athletes. By concentrating performance around the end-point mean location, an increase in spatial error occurred. More spatial and timing errors were observed in non-athletes than athletes, indicating athletes were more certain about likelihood information or their interpretation of likelihood information than non-athletes. These results suggest that athletic experience may facilitate the use of probabilistic information for optimal sensorimotor estimations.

The effect of inherent and incidental constraints on bimanual and social coordination.

The current investigation was designed to examine the influence of inherent and incidental constraints on the stability characteristics associated with bimanual and social coordination. Individual participants (N = 9) and pairs of participants (N = 18, 9 pairs) were required to rhythmically coordinate patterns of isometric forces in 1:1 in-phase and 1:2 multi-frequency patterns by exerting force with their right and left limbs. Lissajous information was provided to guide performance. Participants performed 13 practice trials and 1 test trial per pattern. On the test trial, muscle activity from the triceps brachii muscles of each arm was recorded. EMG-EMG coherence between the two EMG signals was calculated using wavelet coherence. The behavioral data indicated that individual participants performed the 1:1 in-phase pattern more accurately and with less variability than paired participants. The EMG coherence analysis indicated significantly higher coherence for individual participants than for the paired participants during the 1:1 in-phase pattern, whereas no differences were observed between groups for the 1:2 coordination pattern. The results of the current investigation support the notion that neural crosstalk can stabilize 1:1 in-phase coordination when contralateral and ipsilateral signals are integrated via the neuromuscular linkage between two effectors.

Bimanual coordination associated with left- and right-hand dominance: testing the limb assignment and limb dominance hypothesis.

In an experiment conducted by Kennedy et al. (Exp Brain Res 233:181-195, 2016), dominant right-handed individuals were required to produce a rhythm of isometric forces in a 2:1 or 1:2 bimanual coordination pattern. In the 2:1 pattern, the left limb performed the faster rhythm, while in the 1:2 pattern, the right limb produced the faster pattern. In the 1:2 pattern, interference occurred in the limb which had to produce the slower rhythm of forces. However, in the 2:1 condition, interference occurred in both limbs. The conclusion was that interference was not only influenced by movement frequency, but also influenced by limb dominance. The present experiment was designed to replicate these findings in dynamic bimanual 1:2 and 2:1 tasks where performers had to move one wrist faster than the other, and to determine the influence of limb dominance. Dominant left-handed (N = 10; LQ = - 89.81) and dominant right-handed (N = 14; LQ = 91.25) participants were required to perform a 2:1 and a 1:2 coordination pattern using Lissajous feedback. The harmonicity value was calculated to quantify the interference in the trial-time series. The analysis demonstrated that regardless of limb dominance, harmonicity was always lower in the slower moving limb than in the faster moving limb. The present results indicated that for dominant left- and dominant right-handers the faster moving limb influenced the slower moving limb. This is in accordance with the assumption that movement frequency has a higher impact on limb control in bimanual 2:1 and 1:2 coordination tasks than handedness.

The influence of accuracy constraints on bimanual and unimanual sequence learning.

An experiment was designed to determine whether accuracy constraints can influence how unimanual and bimanual motor sequences are produced and learned. The accuracy requirements of the task were manipulated using principles derived from Fitts' Law to create relatively low (ID = 3) and high (ID = 5) accuracy demands. Right-limb dominant participants (N = 28, age = 21.9 yrs; 15 females and 13 males) were required to produce unimanual left, unimanual right or bimanual movement sequences using elbow extension and flexion movements to hit a series of illuminated targets. The targets were illuminated in a repeating sequence of 16 elements. Participants performed 20 practice trials. Thirty minutes following the practice trials participants performed a retention test. Element duration (time interval between target hits) and segment harmonicity (hesitations/adjustments in movement pattern) were calculated. The results indicate longer element duration and lower harmonicity values (more adjustments) when the task required higher accuracy demands (ID = 5) compared to low accuracy demands (ID = 3). Element duration was shorter and harmonicity was higher at ID = 5 for both unimanual groups than the bimanual group. However, element duration was shorter and harmonicity was higher at ID = 3 for the bimanual group than for both unimanual groups. These results indicate that the accuracy demands of the task can influence both performance and learning of motor sequences and suggest differences between unimanual and bimanual motor sequence learning. It appears there is a bimanual advantage for tasks with lower accuracy demands whereas performance is more accurate with unimanual performance, regardless of limb, with higher accuracy demands. These results are consistent with recent research indicating that accuracy requirements change the control processes for bimanual performance differently than for unimanual tasks.

Mathematical model of COVID-19 intervention scenarios for São Paulo-Brazil.

With COVID-19 surging across the world, understanding the effectiveness of intervention strategies on transmission dynamics is of primary global health importance. Here, we develop and analyze an epidemiological compartmental model using multi-objective genetic algorithm design optimization to compare scenarios related to strategy type, the extent of social distancing, time window, and personal protection levels on the transmission dynamics of COVID-19 in São Paulo, Brazil. The results indicate that the optimal strategy for São Paulo is to reduce social distancing over time with a stepping-down reduction in the magnitude of social distancing every 80-days. Our results also indicate that the ability to reduce social distancing depends on a 5-10% increase in the current percentage of people strictly following protective guidelines, highlighting the importance of protective behavior in controlling the pandemic. Our framework can be extended to model transmission dynamics for other countries, regions, states, cities, and organizations.

The Influence of Altered-Gravity on Bimanual Coordination: Retention and Transfer.

Many of the activities associated with spaceflight require individuals to coordinate actions between the limbs (e.g., controlling a rover, landing a spacecraft). However, research investigating the influence of gravity on bimanual coordination has been limited. The current experiment was designed to determine an individual's ability to adapt to altered-gravity when performing a complex bimanual force coordination task, and to identify constraints that influence coordination dynamics in altered-gravity. A tilt table was used to simulate gravity on Earth [90° head-up tilt (HUT)] and microgravity [6° head-down tilt (HDT)]. Right limb dominant participants (N = 12) were required to produce 1:1 in-phase and 1:2 multi-frequency force patterns. Lissajous information was provided to guide performance. Participants performed 14, 20 s trials at 90° HUT (Earth). Following a 30-min rest period, participants performed, for each coordination pattern, two retention trials (Earth) followed by two transfer trials in simulated microgravity (6° HDT). Results indicated that participants were able to transfer their training performance during the Earth condition to the microgravity condition with no additional training. No differences between gravity conditions for measures associated with timing (interpeak interval ratio, phase angle slope ratio) were observed. However, despite the effective timing of the force pulses, there were differences in measures associated with force production (peak force, STD of peak force mean force). The results of this study suggest that Lissajous displays may help counteract manual control decrements observed during microgravity. Future work should continue to explore constraints that can facilitate or interfere with bimanual control performance in altered-gravity environments.

Modeling the effects of intervention strategies on COVID-19 transmission dynamics.

OBJECTIVES: To model the effects of continuous, intermittent, and stepping-down social distancing (SD) strategies and personal protection measures on COVID-19 transmission dynamics. METHODS: Constant, intermittent, and stepping-down SD strategies were modeled at 4 mean magnitudes (5%, 10 %, 15 % and 20 %), 2 time windows (40-days, 80-days), and 2 levels of personal caution (30 % and 50 %). RESULTS: The stepping-down strategy was the best long-term SD strategy to minimize the peak number of active COVID-19 cases and associated deaths. The stepping-down strategy also resulted in a reduction in total time required to SD over a two-year period by 6.5 % compared to an intermittent or constant SD strategy. An 80-day SD time-window was statistically more effective in maintaining control over the COVID-19 pandemic than a 40-day window. However, the results were dependent upon 50 % of people being cautious (engaging in personal protection measures). CONCLUSION: If people exercise caution while in public by protecting themselves (e.g., wearing a facemask, proper hand hygiene and avoid agglomeration) the magnitude and duration of SD necessary to maintain control over the pandemic can be reduced. Our models suggest that the most effective way to reduce SD over a two-year period is a stepping-down approach every 80 days. According to our model, this method would prevent a second peak and the number of intensive care units needed per day would be within the threshold of those currently available.

Accessing interpersonal and intrapersonal coordination dynamics.

Both intrapersonal and interpersonal coordination dynamics have traditionally been investigated using relative phase patterns of in-phase (ϕ = 0°) and/or anti-phase (ϕ = 180°). Numerous investigations have demonstrated that coordination tasks that require other relative phase patterns (e.g., 90°) are difficult or near impossible to perform without extended practice. Recent findings, however, have demonstrated that an individual can produce a wide range of intrapersonal bimanual patterns within a few minutes of practice when provided integrated feedback. The present experiment was designed to directly compare intra- and interpersonal coordination performance and variability when provided Lissajous feedback or pacing metronome. Single participants (N = 12) and pairs of participants (N = 24, 12 pairs) were required to produce relative phase patterns between 0° and 180° in 30° increments using either pacing metronomes or Lissajous displays. The Lissajous displays involved a goal template and a cursor providing integrated feedback regarding the position of the two effectors. The results indicated both single and pairs of participants could effectively produce a large range of coordination patterns that typically act as repellers after only 6 min of practice when provided integrated feedback. However, single participants performed the in-phase coordination pattern more accurately and with less variability than paired participants, regardless of the feedback condition. These results suggest an advantage for intrapersonal coordination when performing in-phase coordination, possibly due to the stabilizing effect occurring via the neuro-muscular linkage between effectors.

Response biases: the influence of the contralateral limb and head position.

Two experiments were designed to determine response biases resulting from production of force in the contralateral limb and head position. Participants were required to react with one limb while tracking a sinewave template by generating a pattern of force defined by the sinewave with the contralateral limb or watching a cursor move through the sinewave. In Experiment 1, participants had to react with their right or left limb while their head was in a neutral position. In Experiment 2, participants had to react with their left limb while their head was turned 60° to the left or right. A color change of the waveform signaled participants to produce an isometric contraction with the reacting limb. Reaction time was calculated as the time interval between the color change of the waveform and the initiation of the response. The results indicated mean reaction time for the left limb was significantly influenced by force production in the right limb. During left limb reactions, reaction time was faster for trials in which both limbs initiated force simultaneously as compared to trials in which the left limb initiated force while the right limb was producing force. Mean reaction time for the right limb was not influenced by force production in the contralateral limb. The results are consistent with the notion that crosstalk can influence the time required to react to stimuli but this influence occurs at the point of force initiation and is asymmetric in nature with the dominant limb exerting a stronger influence on the non-dominant limb than vice versa. However, we did not find a similar effect for head position via the tonic neck response.

Intentional Switching Between Bimanual Coordination Patterns.

Previous theoretical and empirical work indicates that intentional changes in a bimanual coordination pattern depends on the stability of the bimanual coordination pattern (Kelso, Schotz, & Schöner, 1988; Scholz & Kelso, 1990). The present experiments retest this notion when online Lissajous displays are provided. Switching to and from in-phase and antiphase and to and from 90° and 270° were tested in Experiment 1. Participants were able to very effectively produce the 180°, 90°, and 270° coordination patterns although performance of the in-phase coordination task was even more stable. The data indicated that switching to in-phase from antiphase was more rapid than vice versa and that switching times between 90° to 270° were similar. Experiment 2 investigated switching between 1:2 and 2:1 bimanual coordination patterns. The results indicated that switching time was similar between the 2:1 and 1:2 coordination tasks and that increases in stability over practice resulted in additional decreases in switching times. This provides additional evidence that the attractor landscape is fundamentally different dependent on the type of information provided the performer. What remains to be done is to reconcile these results with the various theories/perspectives currently used to describe and explain bimanual coordination.

The simplest acquisition protocol is sometimes the best protocol: performing and learning a 1:2 bimanual coordination task.

An experiment was conducted to determine if the performance and learning of a multi-frequency (1:2) coordination pattern between the limbs are enhanced when a model is provided prior to each acquisition trial. Research has indicated very effective performance of a wide variety of bimanual coordination tasks when Lissajous plots with goal templates are provided, but this research has also found that participants become dependent on this information and perform quite poorly when it is withdrawn. The present experiment was designed to test three forms of modeling (Lissajous with template, Lissajous without template, and limb model), but in each situations, the model was presented prior to practice and not available during the performance of the task. This was done to decrease dependency on the model and increase the development of an internal reference of correctness that could be applied on test trials. A control condition was also collected, where a metronome was used to guide the movement. Following less than 7 min of practice, participants in the three modeling conditions performed the first test block very effectively; however, performance of the control condition was quite poor. Note that Test 1 was performed under the same conditions as used during acquisition. Test 2 was conducted with no augmented information provided prior to or during the performance of the task. Only participants in the limb model condition were able to maintain performance on Test 2. The findings suggest that a very simple intuitive display can provide the necessary information to form an effective internal representation of the coordination pattern which can be used guide performance when the augmented display is withdrawn.

The influence of asymmetric force requirements on a multi-frequency bimanual coordination task.

An experiment was designed to determine the impact of the force requirements on the production of bimanual 1:2 coordination patterns requiring the same (symmetric) or different (asymmetric) forces when Lissajous displays and goal templates are provided. The Lissajous displays have been shown to minimize the influence of attentional and perceptual constraints allowing constraints related to neural crosstalk to be more clearly observed. Participants (N=20) were randomly assigned to a force condition in which the left or right limb was required to produce more force than the contralateral limb. In each condition participants were required to rhythmically coordinate the pattern of isometric forces in a 1:2 coordination pattern. Participant performed 13 practice trials and 1 test trial per force level. The results indicated that participants were able to effectively coordinate the 1:2 multi-frequency goal patterns under both symmetric and asymmetric force requirements. However, consistent distortions in the force and force velocity time series were observed for one limb that appeared to be associated with the production of force in the contralateral limb. Distortions in the force produced by the left limb occurred regardless of the force requirements of the task (symmetric, asymmetric) or whether the left or right limb had to produce more force than the contralateral limb. However, distinct distortions in the right limb occurred only when the left limb was required to produce 5 times more force than the right limb. These results are consistent with the notion that neural crosstalk can influence both limbs, but may manifest differently for each limb depending on the force requirements of the task.

Data from a pre-publication independent replication initiative examining ten moral judgement effects.

We present the data from a crowdsourced project seeking to replicate findings in independent laboratories before (rather than after) they are published. In this Pre-Publication Independent Replication (PPIR) initiative, 25 research groups attempted to replicate 10 moral judgment effects from a single laboratory's research pipeline of unpublished findings. The 10 effects were investigated using online/lab surveys containing psychological manipulations (vignettes) followed by questionnaires. Results revealed a mix of reliable, unreliable, and culturally moderated findings. Unlike any previous replication project, this dataset includes the data from not only the replications but also from the original studies, creating a unique corpus that researchers can use to better understand reproducibility and irreproducibility in science.

Life span changes: Performing a continuous 1:2 bimanual coordination task.

The experiment was conducted to determine the influence of mirror movements in bimanual coordination during life span. Children, young adults, and older adults were instructed to perform a continuous 1:2 bimanual coordination task by performing flexion-extension wrist movements over 30s where symmetrical and non-symmetrical coordination patterns alternate throughout the trial. The vision of the wrists was covered and Lissajous-feedback was provided online. All age groups had to perform 10 trials under three different load conditions (0kg, .5kg, 1.0kg: order counterbalanced). Load was manipulated to determine if increased load increases the likelihood of mirror movements. The data indicated that the performance of the young adults was superior compared to the children and older adults. Children and older adults showed a stronger tendency to develop mirror movements and had particular difficulty in performing the non-symmetrical mode. This type of influence may be attributed to neural crosstalk.

Continuous scanning trials:Transitioning through the attractor landscape.

Bimanual 1:1 coordination patterns other than in-phase (0°) and anti-phase (180°) have proven difficult to perform even with extended practice. The difficulty has traditionally been attributed to phase attraction that draws the coordination between the limbs towards the bimanual patterns of in-phase and anti-phase and variability associated with the activation and associated proprioceptive signals of non-homologous muscles via crossed and uncrossed cortical pathways. However, recent experiments have demonstrated that a wide range of relative phase and multi-frequency coordination patterns can be effectively produced with only a few minutes of practice when Lissajous or online relative phase information is provided. The present experiment was designed to determine if participants provided Lissajous feedback comprised of continuously transitioning relative phase goals could be effectively performed as the participant navigates through the attractor landscape. The results clearly indicated that participants can effectively produce a large range of supposedly unstable coordination patterns (between 0° and 180° in 1° increments) after only a few minutes of practice. These findings clearly indicate that the perception-action system is fully capable of effectively producing and transitioning through a wide range of bimanual coordination patterns and that the reason for the failure to produce these patterns in previous experiments resides in the perceptual information and attentional requirements typically found in experimental testing environments.

Perception and action influences on discrete and reciprocal bimanual coordination.

For nearly four decades bimanual coordination, "a prototype of complex motor skills" and apparent "window into the design of the brain," has been intensively studied. Past research has focused on describing and modeling the constraints that allow the production of some coordination patterns while limiting effective performance of other bimanual coordination patterns. More recently researchers have identified a coalition of perception-action constraints that hinder the effective production of bimanual skills. The result has been that given specially designed contexts where one or more of these constraints are minimized, bimanual skills once thought difficult, if not impossible, to effectively produce without very extensive practice can be executed effectively with little or no practice. The challenge is to understand how these contextual constraints interact to allow or inhibit the production of complex bimanual coordination skills. In addition, the factors affecting the stability of bimanual coordination tasks needs to be re-conceptualized in terms of perception-related constraints arising from the environmental context in which performance is conducted and action constraints resident in the neuromotor system.

Symmetrical and asymmetrical influences on force production in 1:2 and 2:1 bimanual force coordination tasks.

Results from a recent experiment (Kennedy et al. in Exp Brain Res 233:181-195, 2015) indicated consistent and identifiable distortion of the left limb forces that could be attributable to the production of right limb forces during a multi-frequency bimanual force task. However, distortions in the forces produced by the right limb that could be attributable to the production of force in the left limb were not observed. The present experiment was designed to replicate this finding and determine whether the influence of force produced by one limb on the contralateral limb is the result of the limb assigned the faster frequency on the limb performing the slower frequency or a bias associated with limb dominance. Participants (N = 10) were required to rhythmically coordinate a pattern of isometric forces in a 1:1, 1:2, or 2:1 coordination pattern. The 1:2 task required the right limb to perform the faster rhythm, while the 2:1 task required the left limb to perform the faster rhythm. The 1:1 task was used as a control. Participants performed 13 practice trials and 1 test trial per task. Lissajous displays were provided to guide performance. If the limb assigned the faster frequency was responsible for the distortions observed in the contralateral limb, it was hypothesized that distortions would only be observed in the force trace of the limb producing the slower pattern of force. If a bias associated with limb dominance was responsible for the distortions observed in the contralateral limb, it was hypothesized that in right-limb-dominant participants the right limb would influence the left limb, regardless of limb assignment. Replicating the results of the previous experiment, only distortions in the left limb were observed in the 1:2 coordination task that could be attributed to the production of force by the right limb. However, identifiable distortions were observed in the force produced by both the left and right limb in the 2:1 coordination task. Observed distortions in the left limb, when assigned the faster rhythm indicated that the source of interference is not limited to limb assignment but also a function of limb dominance.

Bimanual force control: cooperation and interference?

Three experiments were designed to determine the level of cooperation or interference observed from the forces generated in one limb on the forces exhibited by the contralateral limb when one or both limbs were producing a constant force (Experiment 1), one limb was producing a dynamic force while the other limb was producing a constant force (Experiment 2), and both limbs were producing dynamic force patterns (Experiment 3). The results for both Experiments 1 and 2 showed relatively strong positive time series cross correlations between the left and right limb forces indicating increases or decreases in the forces generated by one limb resulted in corresponding changes in the forces produced by the homologous muscles of the contralateral limb. Experiment 3 required participants to coordinate 1:1 and 1:2 rhythmical bimanual force production tasks when provided Lissajous feedback. The results indicated very effective performance of both bimanual coordination patterns. However, identifiable influences of right limb forces on the left limb force time series were observed in the 1:2 coordination pattern but not in the 1:1 pattern. The results of all three experiments support the notion that neural crosstalk is partially responsible for the stabilities and instabilities associated with bimanual coordination.