Use of natural antioxidants for the correction of changes in general and local parameters of lipid peroxidation and antioxidant defense system during experimental eye burn.

The effect of natural antioxidants in grade III chemical eye burn was studied in experiments on rabbits at various stages of burn disease. The use of histochrome, Gingko Biloba, and diquertin in combination with complex drug therapy decelerated the decrease in the antioxidant potential of tear fluid and blood plasma. This treatment was also followed by a decrease in the concentration of end products of free radical oxidation.

Antioxidant potential of tear fluid and blood plasma in rabbits with grade III chemical eye burn at various stages of burn disease.

The antioxidant potential of tear fluid and plasma in rabbits with chemical eye burn of grade III was measured at various stages of burn disease. Eye burns were accompanied by depletion of the antioxidant system in tear fluid and plasma and impairment of antioxidant defense in the whole organism. These changes contribute to activation of free radical lipid peroxidation. The pathological changes in the organism and eye were most pronounced at the stage of trophic disturbances.