RESUMO
Changes in the serotonin and 5-oxyindolacetic acid contents in mitochondrial fractions of different brain structures were studied prior to and after oxytocin intraventricular microinjection in normal and drug-dependent rats. The oxytocin administration exerted different effects on serotonin metabolism in different brain structures. The drug-dependent animals showed a higher level of the brain serotonin as compared to the control. The oxytocin administration decreased hypothalamic and hippocampal serotonin levels. The oxytocin effect on the processes of drug dependence is discussed.
Assuntos
Encéfalo/efeitos dos fármacos , Dependência de Heroína/fisiopatologia , Ocitocina/farmacologia , Receptores de Serotonina/efeitos dos fármacos , Animais , Encéfalo/fisiologia , Ácido Hidroxi-Indolacético/metabolismo , Injeções Intraventriculares , Masculino , Mitocôndrias/efeitos dos fármacos , Mitocôndrias/metabolismo , Ratos , Ratos Endogâmicos , Receptores de Serotonina/fisiologia , Serotonina/metabolismoRESUMO
Light stimulation affected the monoamine oxidase activity in mitochondria of dog visual analyzer structures. The enzymatic activity was elevated as the mitochondrial fraction was increased in brain visual cortex (area 17) and in lateral geniculate body at the period from the 1 to the 21 day after birth. Light stimulation led to maximal increase in monoamine oxidase activity in the anterior colliculus of dog brain visual cortex (area 17) within 21 day after birth and in the lateral geniculate body--within the 45 day.