RESUMO
A case of common variable hypogammaglobulinaemia with associated impairment of cell mediated immunity and severe wart virus infection is described. The defect of cell mediated immunity is thought to have predisposed this patient to the development of persistent wart infection which in turn grossly depressed the body's cellular immunity and thus allowed widespread dissemination of the warts. The rapid restoration of cell mediated immunity which followed the reduction in the antigenic load of wart virus by diathermy treatment was followed by the spontaneous regression of all the patient's warts. This unusual case may provide some insight into the complex relationship between wart virus infection and the immune system of the host.
Assuntos
Agamaglobulinemia/complicações , Verrugas/etiologia , Adulto , Linfócitos B , Diatermia , Seguimentos , Humanos , Imunidade Celular , Contagem de Leucócitos , Ativação Linfocitária , Masculino , Microscopia Eletrônica , Linfócitos T , Verrugas/imunologia , Verrugas/terapiaAssuntos
Adenocarcinoma/sangue , Células da Medula Óssea , Medula Óssea , Neoplasias da Mama/sangue , Tumor Carcinoide/sangue , Carcinoma/sangue , Eritrócitos , Irradiação Hipofisária , Idoso , Contagem de Células Sanguíneas , Transfusão de Sangue , Neoplasias Ósseas , Neoplasias da Mama/complicações , Neoplasias da Mama/radioterapia , Neoplasias da Mama/cirurgia , Feminino , Humanos , Pessoa de Meia-Idade , Metástase Neoplásica , Cuidados Paliativos , Complicações Pós-Operatórias , Radioisótopos , Isótopos de ÍtrioRESUMO
Further investigations into the mechanism by which CCl(4) administration to Sprague-Dawley rats protects them against the adrenocorticolytic action of dimethylbenz(a)anthracene (DMBA) are reported. The results show that CCl(4) must be given shortly before DMBA to achieve the best protection and that treatments given after DMBA are ineffective. It was established that the hepatotoxicity of CCl(4) in these experiments was related reciprocally to the adrenocorticolytic effect of DMBA.Protection with butter yellow (DAB) was achieved only when sufficient time elapses for drug metabolism to be stimulated in the liver. Butter yellow given after DMBA has no protective effect but the prior exposure of the rats to DMBA potentiates the hepatotoxic effects of DAB.Partial hepatectomy gives protection when performed 1 day before DMBA; shorter intervals give no protection. Some protection can be achieved with resection 6 or 24 hours after DMBA.
