[Changes in the hypophyseal-thyroid system under narcotic action in the parturients of a group at high risk of perinatal pathology]. / Izmenenie gipofizarno-tireoidnoi sistemy v usloviiakh narkoticheskogo deistviia u rozhenits gruppy vysokogo riska perinatal'noi patologii.

Eighty-seven parturients were examined to disclose the function of the thyroid during narcotic exposure in labor and in cesarean section in cases of high risk of giving birth to infants with perinatal abnormalities. Neurotropic agents were found to inhibit the fetal hypophyseo-thyroid system in cases with a history of intrauterine hypoxia, thus saving this system from exhaustion. Employment of various types of general anesthesia in cesarean section in this patient population provides an adequate maternal neurovegetative protection from surgical aggression.

[Clinico-biological evaluation of the status of newborn infants and the tactics in the management of the early postnatal period]. / Kliniko-biologicheskaia otsenka sostoianiia detei pri rozhdenii i taktika vedeniia rannego postnatal'nogo perioda.

Biology of the perinatal period as a basis of neonatal management is an area of conceptual controversy. Literature evidence and findings of a clinical and functional study in 175 term newborns support the concept of intrapartum and neonatal stress. This is a rationale for a strategy of maintaining the adaptive mechanisms of the fetus and newborn in a maximal range and active support of neonatal homeostasis. Narcotic depression, prolonged hypothermia++ of various origins are considered as factors endangering the postnatal adaptation.

[The causes of infertility in hyperprolactinemia]. / O prichinakh besplodiia pri giperprolaktinemii.

A study was made of function of the hypothalamohypophyseal system in women with infertility combined with hyperprolactinemia. Changes in the levels of prolactin, LH, FSH and TSH in response to the administration of releasing hormones (gonado- and thyroliberin) and metoclopramide (dopamine antagonist) were determined in 28 women with hyperprolactinemic amenorrhea and in 5 women with a normal menstrual cycle. Resistance of lactotrophs to functional tests was revealed. It grew with an increase in a prolactin level. On the contrary, a response of gonado- and thyrotrophs to functional tests grew with an increase in a degree of hyperprolactinemia. The authors arrived at a conclusion that stable hyperprolactinemia resulted from disorder of the receptor apparatus of lactotrophs with the resultant nonsusceptibility of the latter to an inhibitory effect of dopamine to prolactin secretion. Proceeding from their own and literature data, the authors propose for discussion a scheme of fertility disturbance in stable hyperprolactinemia.

[Repair processes in wound tissues of experimental animals following administration of glycine]. / Issledovanie reparativnykh protsessov v tkaniakh ran éksperimental'nykh zhivotnykh posle vvedeniia glitsina.

A study was made of the effect of glycine given in doses approximating the physiological ones on the repair of processes in rat wound tissues. It was disclosed that in the early periods of wound healing, glycine administration leads to the increased content of cAMP and cAMP/cGMP ratio in the wound muscle and then in the granulation tissue, which appears to promote the intensification of the repair processes manifesting in the changes in tissue metabolism (DNA, collagen), in anti-inflammatory action, as well as in a more rapid maturation of the granulation tissue and wound reduction. It was also found that the doses of glycine tested do not affect the content of insulin and hydrocortisone in the blood of experimental animals.