"Why Don't You Go Into Suburbs? Why Are You Targeting Us?": Trust and Mistrust in HIV Vaccine Trials in South Africa.

Trust is a key element of high-quality stakeholder relations, which are themselves essential for the success of HIV vaccine trials. Where trust is absent, community stakeholders might not volunteer to become involved in key trial activities, and potential participants might not volunteer for enrollment. We explored site staff and Community Advisory Board (CAB) members' experiences of trust/mistrust among community members and potential participants. We analyzed 10 focus group discussions with site staff and CAB members at two active South African HIV vaccine trial sites. We report on key characteristics perceived to contribute to the trustworthiness of communicators, as well as factors associated with mistrust. Attributes associated with trustworthy communicators included shared racial identity, competence, and independence (not being "captured"). Key foci for mistrust included explanations about site selection, stored samples, vaccination, and Vaccine Induced Sero-Positivity (VISP). Our findings suggest that community members' trust is not necessarily global, in which trials are trusted or not; rather, it appears fairly nuanced and is impacted by various perceived attributes of communicators and the information they provide. We make recommendations for clinical trial site stakeholders invested in building trust and for future research into trust at these sites.

Beyond the two-group paradigm in studies of intergroup conflict and inequality: Third parties and intergroup alliances in xenophobic violence in South Africa.

Social psychologists typically conceptualize intergroup processes in terms of unequal pairs of social categories, such as an advantaged majority (e.g., 'Whites') and a disadvantaged minority (e.g., 'Blacks'). We argue that this two-group paradigm may obscure the workings of intergroup power by overlooking: (1) the unique dynamics of intergroup relations involving three or more groups, and (2) the way some two-group relationships function as strategic alliances that derive meaning from their location within a wider relational context. We develop this argument through a field study conducted in a grape-farming town in South Africa in 2009, focusing on an episode of xenophobic violence in which a Zimbabwean farm worker community was forcibly evicted from their homes by their South African neighbours. Discursive analysis of interview accounts of the nature and origins of this violence shows how an ostensibly binary 'xenophobic' conflict between foreign and South African farm labourers was partially constituted through both groups' relationship with a third party who were neither victims nor perpetrators of the actual violence, namely White farmers. We highlight some potential political consequences of defaulting to a two-group paradigm in intergroup conflict studies.

". . . I've Gone Through This My Own Self, So I Practice What I Preach . . . ".

There has not been enough study of the processes by which site staff help participating community members and potential participants to understand complicated concepts for HIV vaccine trials. This article describes strategies reported in six focus group discussions with Community Advisory Board members, educators, and consent counselors at an active HIV vaccine trial site in South Africa. Thematic analysis identified a considerable range of strategies, and findings suggest that such staff do not only try to promote understanding of critical information but also try to build trust in communicated information, to respect cultural differences, and to promote voluntariness. Findings also suggest occasional tensions between these implicit goals. Actual engagement and consent encounters at HIV vaccine trial sites should be observed, recorded, and analyzed; and the relationship between practices and valued outcomes should be assessed. These efforts may help to make consent-related encounters as "potent" as possible given finite resources.