Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
J Invest Surg ; 35(9): 1673-1678, 2022 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-35836365

RESUMO

BACKGROUND: Dermal blood flow is crucial for wound healing and survival of flaps in dermatologic surgery. To improve flap viability in cases of compromised perfusion topical agents can easily be applied. The aim of this placebo-controlled study was to characterize changes of DBF in healthy subjects by quantitatively assessing perfusion dynamics after application of capsaicin to establish a reference for measurements at injured sites. METHODS: In 46 healthy subjects perfusion dynamics after local application with capsaicin and placebo was noninvasively assessed, determining cutaneous oxygen saturation, relative hemoglobin count and blood flow using an Oxygen-to-See device. RESULTS: A significant raise in superficial (162% p = 0.000) and deep (144%, p = 0.000) skin oxygenation after 30 min was provoked. A highly significant raise in measurements of flow and velocity was present in superficial (523%, p = 0.000) and deep (242%, p = 0.000) sites. CONCLUSION: With the introduced model applied to observe changes in parameters of dermal blood flow in healthy subjects the authors can reliably monitor effects of topically administered capsaicin. This baseline can be used as reference for further studies in the settings of endangered flap survival or critically perfused wounds as has been proven in animal studies.


Assuntos
Capsaicina , Pele , Administração Tópica , Capsaicina/farmacologia , Humanos , Fluxometria por Laser-Doppler , Microcirculação
2.
Dermatol Surg ; 46(12): 1593-1598, 2020 12.
Artigo em Inglês | MEDLINE | ID: mdl-32852421

RESUMO

BACKGROUND: Topical anesthetics are used in noninvasive transdermal anesthesia to decrease the superficial pain sensation threshold during dermatologic surgery. Combined pain relief and sensitivity loss can avoid discomfort during the surgery. OBJECTIVE: The aim of this placebo-controlled study was to compare the efficacy of 3 commonly used topical agents by collating loss of sensitivity over time. MATERIALS AND METHODS: Three topical anesthetic creams, a topical anti-inflammatory cream, and a moisturizing cream were applied on the left volar forearm of each of the 48 healthy Caucasian participants. Sensitivity was assessed with the dynamic 2-point discrimination and the Semmes-Weinstein test at 0, 60, 90, 120, 150, and 180 minutes after cream application. RESULTS: After 180 minutes, benzocaine showed a significantly lower 2-point discrimination reduction than lidocaine alone and a lidocaine and prilocaine mixture. Sensory threshold measurements by the Semmes-Weinstein test after 60 minutes revealed a significantly higher effect with lidocaine alone and with the lidocaine and prilocaine mixture than with benzocaine. CONCLUSION: The authors found a stronger skin sensitivity reduction by the eutectic lidocaine and prilocaine mixture and lidocaine alone compared with benzocaine. We suggest increased discomfort reduction in topical anesthetic supported dermatologic surgery by the eutectic mixture and lidocaine alone.


Assuntos
Anestesia Local/métodos , Anestésicos Locais/administração & dosagem , Procedimentos Cirúrgicos Dermatológicos/efeitos adversos , Limiar da Dor/efeitos dos fármacos , Dor Pós-Operatória/prevenção & controle , Adolescente , Adulto , Anestésicos Combinados/administração & dosagem , Anti-Inflamatórios/administração & dosagem , Benzocaína/administração & dosagem , Método Duplo-Cego , Feminino , Antebraço , Voluntários Saudáveis , Humanos , Combinação Lidocaína e Prilocaína/administração & dosagem , Masculino , Pessoa de Meia-Idade , Nociceptividade/efeitos dos fármacos , Medição da Dor/estatística & dados numéricos , Dor Pós-Operatória/etiologia , Creme para a Pele/administração & dosagem , Resultado do Tratamento , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...