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Pediatr Transplant ; 19(2): E37-40, 2015 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-25495657

RESUMO

We present a case report of intramuscular autotransplantation of the parathyroid cell suspension acquired after total parathyroidectomy. A 15-yr-old female patient who had been undergoing hemodialysis due to chronic renal failure for eight yr was diagnosed with secondary hyperthyroidism and subsequently underwent total parathyroidectomy. The parathyroid cells were acquired from the resected tissues, processed through isolation and cultivation phases, and counted using a cell counter. A total of two million cells were injected into the left deltoid muscle using a 22-gauge needle. After surgery, five and 10 million cells were injected in the fifth and 12 week, respectively. The desired serum levels of parathyroid hormones and calcium were not achieved after the first two transplantations. In addition, there was no regression in the patient's symptoms. However, at four wk after the third transplantation, serum parathyroid hormone level did not decrease to <3 pg/mL, the patient was asymptomatic, and the oral treatment was stopped. Our findings indicate that this new technique is applicable because it is minimally invasive, and it can be easily repeated.


Assuntos
Transplante de Células/métodos , Hipertireoidismo/terapia , Glândulas Paratireoides/citologia , Transplante Autólogo/métodos , Adolescente , Cálcio/metabolismo , Feminino , Humanos , Hipertireoidismo/complicações , Falência Renal Crônica/complicações , Falência Renal Crônica/cirurgia , Procedimentos Cirúrgicos Minimamente Invasivos , Glândulas Paratireoides/transplante , Hormônio Paratireóideo/metabolismo , Paratireoidectomia , Diálise Renal , Resultado do Tratamento
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