[Use of data bank on tuberculosis patients and of computer program for clinical and immunological analysis]. / Ispol'zovanie banka dannykh o bol'nykh tuberkulezom i komp'iuternoí programmy dlia kliniko-immunologicheskogo analiza.

Three hundred and twenty patients with pulmonary tuberculosis were clinically and immunologically compared. The findings support the significance and prospects for using a personal computer while making clinical and laboratory comparisons in different groups of patients for a prompt and objective analysis of available data. Comparative evaluation of the informative value of immunologic tests have indicated that in relation to the major clinical parameters of a tuberculous process, differences are great in those characterizing both T- and B-cell, and specific antimycobacterial immunity. The clinical and immunological findings regarding the specific features of a tuberculosis process may serve as the basis for multidimensional analysis and development of criteria for computer-aided clinical and immunological diagnosis of tuberculosis.

[Tuberculin-provocation immunological tests in the diagnosis of pulmonary tuberculosis]. / Tuberkulinoprovokatsionnye immunologicheskie testy v diagnostike tuberkuleza legkikh.

Prior to and after administration of subcutaneous tuberculin (50 TU) 50 tuberculous and 84 patients with pulmonary tumors, pneumonia, cysts, echinococcosis were examined for immunologically active proteins (IgG, IgA, C3c) and individual serum proteins (alpha2-macroglobulin, alpha1-antitripsin, fibrinogen, acid alpha-glycoprotein). Blast-transformation and migration inhibition on PPI reactions were also conducted. It was established that the above tuberculin-provocative tests may be employed with different efficacy in different clinical situations. Tests for cell immunity are applicable in large well-equipped hospitals. Tests for immunologically active proteins and serum proteins of different functional groups are more suitable for wide practice.

[Principles and methods of immunodiagnosis in tuberculosis]. / Printsipy i metody immunodiagnostiki tuberkuleza.

The paper provides data on the current principles of tuberculosis immunodiagnosis, characterizes agents (antibodies, antigens, recombinant proteins, anti-idiotypes) used for these purposes, describes some difficulties arising in designing antigen and antibody diagnostic kits, presents the results of using various agents for the immunodiagnosis (primarily for serodiagnosis) of tuberculosis, discusses the diagnostic problems of tuberculosis during mass surveys and at tuberculosis hospitals. The results obtained at the Central Research Institute of Tuberculosis are given on the above issues along with references.