1.
Science
; 213(4510): 913-5, 1981 Aug 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6114560
RESUMO
Species of somatostatin of higher molecular weight were present in the nerve terminals (synaptosomes) of ovine stalk median eminences and were released by depolarizing stimuli. One of these species was identified as the biologically active molecule octacosa somatostatin. Octacosa somatostatin appears therefore to be secreted into the hypothalamic-hypophyseal system, supporting the concept of a role for this peptide in regulating pituitary hormone secretion.
Assuntos
Sistema Hipotálamo-Hipofisário/metabolismo , Eminência Mediana/metabolismo , Somatostatina/metabolismo , Animais , Calcimicina/farmacologia , Ionóforos/farmacologia , Potenciais da Membrana , Peso Molecular , Precursores de Proteínas/metabolismo , Radioimunoensaio , Taxa Secretória/efeitos dos fármacos , Ovinos , Sinaptossomos/metabolismo
2.
J Mol Cell Cardiol
; 6(1): 39-47, 1974 Feb.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4150251