[The drug "Selena" in the complex treatment of patients with chronic inflammatory diseases of the biliary system]. / Preparat "Selena" v kompleksnomu likuvanni khvorykh na khronichni zapal'ni zakhvoriuvannia biliarnoï systemy.

The drug selena of the Novamed firm has been shown to be of high clinical, biochemical, and immunological effectiveness in a combined treatment of patients with chronic inflammatory diseases of the biliary system presenting with immunological disorders, that was evidenced by a sooner than in controls disappearance or alleviation of clinical manifestations of the disease, normalization of clinical indices for blood, ultrastructure of the immunocompetent cells, and by less time for the functional state of the liver to return to normal. It is suggested that the drug effect on the immune system might be mediated through normalization of lipid peroxidation and of the system for antioxidant defence.

[Progress of immune system indices in the treatment of chronic inflammatory diseases of the biliary duct]. / Dynamika poraznykiv imunnoï systemy pry likuvanni khronichnykh zapal'nykh zakhvoriuvan' biliarnoï systemy.

In 105 patients with chronic inflammatory illness of gallbladder and biliary ducts the generally-accepted therapy have influenced the IgM and IgG contents in serum, the lymphocytes sensibilization to the tissue antigens of gallbladder, liver, pancreas, the titre of antibodies to this antigens only. The authors insist on necessity of supplementary application of immunomodulating agents in the complex of patients treatment, especially if reactive hepatitis or pancreatitis is present.

[Clinical-immunological research in chronic inflammatory diseases of the biliary tract]. / Kliniko-imunolohichni doslidzhennia pry khronichnykh zapal'nykh zakhvoriuvanniakh biliarnoï systemy.

Complex investigation of the immune state of 123 patients with chronic inflammatory diseases of biliary system (CDBS) was conducted. The reduce of T-lymphocytes quantity and functional activity, their subpopulations, level of complement, the blood serum lysozyme, the increase of B-lymphocytes content, serumal IgG, IgM, circulating immune complexes (CIC), the antibodies titer to the gallbladder tissue, liver, pancreas, and level of the lymphocytes sensibilization to these antigens in the acute period of the disease. Presence of calculi in gallbladder, coexistence of cholecystitis with reactive hepatitis or pancreatitis caused more significant changes in immune system.

[Long-term results of therapy for idiopathic hypothyrosis depending on the immune status]. / Otdalënnye rezul'taty terapii idiopaticheskogo gipotireoza v zavisimosti ot immunnogo statusa.

Impaired immunity in patients with idiopathic hypothyrosis affects negatively the disease course. Such patients developed exacerbations more frequently than patients with normal immune characteristics.

[The use of immunoregulator preparations in the combined treatment of idiopathic hypothyroidism]. / Primenenie immunoreguliruiushchikh preparatov v kompleksnom lechenii idiopaticheskogo gipotireoza.

A comparative analysis of idiopathic hypothyroidism (IHT) outcomes in different therapeutic regimens which incorporated or did not incorporate splenin and sodium nucleinate showed more frequent disease exacerbations in patients who received no immunoactive drugs. Combined therapy reduced the number of patients with decompensation 3.7-fold. Stable IHT compensation was achieved in those patients who had received adjuvant splenin in 80.8% of cases, sodium nucleinate in 86.2% against a 40.9% response rate under conventional replacement therapy with thyreoidin.

[The incidence and nature of hepatobiliary system diseases in workers of the Ternopol Clothing Association]. / Chastota i kharakter zabolevanii gepatobiliarnoi sistemy u rabochikh Ternopol'skogo shveinogo ob''edineniia.

A detailed clinico-laboratory examination of workers of Ternopol sewing factories revealed in 13.9% chronic inflammatory diseases of the hepatobiliary system which exceeds 4 times the indices of seeking medical advice (3.5%) mainly due to latent course. Entropy of blood serum protein data are more informative than bilirubin and transaminase data used in evolution of homeostasis disorders in these patients.