[Effect of angiotensin converting enzyme lisinopril on the state of vascular bed in premenopausal women with arterial hypertension].

We assessed effect of lisinopril on structural-functional state of vascular bed in 82 premenopausal women with hypoestrogenia and arterial hypertension (AH). Test with postocclusion reactive hyperemia showed that at the background of significant lowering of endothelial vasomotor function before treatment 47.5% of women had inertial type of vasomotor reaction. This evidenced for considerable role of dyshormonal states in progression of AH first of all at the account of increase of vascular stiffness and development of endothelial dysfunction. Lisinopril improved structural-functional state of vascular wall of common carotid arteries, affected positively dysfunction of endothelium, lowered stiffness of arterial vascular wall.

[Effect of hypoestrogenemia on quality of life of premenopausal women with arterial hypertension].

Quality of life (QL) of premenopausal women (n = 76) with arterial hypertension (AH) with normal and low level of estradiol was studied with the use of Short Form 36 Health Quality Survey. QL of women with estrogen deficit was significantly worse than QL of premenopausal female patients with preserved estrogen level.

[Structural and functional parameters of the vascular bed in premenopausal hypertensive women].

AIM: To study structural and functional characteristics of the vascular bed in premenopausal women with arterial hypertension (AH) and changes in hormone levels. MATERIAL AND METHODS: Duplex scanning of the common carotid arteries (CCA) was made in 180 females with premenopausal hypertension. RESULTS: Hypertensive women in premenopause with sexual hormones unbalance exhibited a wide CCA lumen in the absence of hemodynamically significant stenosis. This evidences for marked structural and functional changes of the vascular wall in the form of arteriosclerosis. Such patients' postocclusive reactive hyperemia test demonstrates a significant decline of vasomotor endothelial function, 43% cases show an inertial type of the vasomotor reaction reflecting an important role of hormonal unbalance in AH progression primarily due to increased stiffness of the vascular wall and endothelial dysfunction. CONCLUSION: Premenopausal women with hypertension and hormonal unbalance should be examined with consideration of the fact that impaired status of sexual hormones is an independent factor of risk of AH progression and they should be referred to a separate group of follow-up. Their treatment policy must be formed by both cardiologist and gynecological endocrinologist.

[Comparison of dysrhythmias in women with hypertension in the period of premenopause and in late fertile period with altered hormonal background in dependence on the variant of left ventricular modeling].

We carried out 24 hour Holter ECG monitoring in 106 women with hypertension in the period of premenopause and in late fertile period with altered hormonal background. Comparative analysis of character and structure of dysrhythmias showed that supraventricular premature beats including rapid and allorhythmic extrasystoles were more often registered among premenopausal women than among patients in fertile period. Same tendencies took place concerning frequency of ventricular rhythm disturbances (in most cases I grade II-IV ventricular extrasystoles). Comparative analysis of dysrhythmias in premenopausal and fertile hypertensive women with normal left ventricular geometry and with hypertrophic type of remodeling showed that both supraventricular and ventricular rhythm disturbances were significantly more often registered in hypertrophic variants of left ventricular remodeling, especially in premenopausal women.

[Evaluation of long-term therapy influence with angiotensin converting enzyme inhibitor lisinopril on morphofunctional parameters of the left ventricle, peripheral artery endothelium disfunction and painless myocardial ischemia in premenopausal women with hypertension].

Aim of the study was to assess influence of long-term therapy with angiotensin converting enzyme inhibitor lisinopril on morphofunctional parameters of the left ventricle (LV) and painless myocardial ischemia in 109 premenopausal women with stage II hypertension depending on functional state of peripheral artery endothelium. The results show that lisinopril therapy in premenopausal women with hypertension can stop or even cause regression of LV myocardial hypertrophy and produce favorable effect on LV remodeling mostly in women with concentric type of hypertrophy and/or without endothelial dysfunction, and has positive effect on frequency of painless myocardial ischemia events.

[The process of remodeling of left chambers of the heart and dysfunction of endothelium of peripheral vessels in hypertensive premenopausal women].

Results of ultrasound study of 230 premenopausal women with I-II stage essential hypertension (EH) in relation to functional state of endothelium of peripheral arteries are presented. Endothelial dysfunction in hypertensive premenopausal women can be one of factors contributing to remodeling of left cardiac chamber. Women with EH and endothelial dysfunction compared with those with conserved vascular endothelial function more often had hypertrophic variants of left ventricular myocardial remodeling (mostly of concentric type). Premenopausal women with EH had diastolic dysfunction of the left ventricle with impairment of both its rigidity and active relaxation, more pronounced in the presence of dysfunction of endothelium of peripheral vessels.