[Skin reactions of delayed hypersensitivity in melanoblastoma]. / Kozhnye reaktsii zamedlennoi giperchuvstvitel'nosti u bol'nykh melanoblastomoi.

Cell factors of nonspecific immunity were estimated in 99 patients with different stages of melanoblastoma by delayed hypersensitivity skin test to tuberculin and DNCB (2,4-dinitrochlorobenzene). The skin test to DNCB is found to correlate with the clinical manifestations of the disease, while the skin test to tuberculin is not related with the degree of tumor spread. It is considered not rational to use the test concerned to define one of the immune cell factors in patients with melanoblastoma during the tumor progression.

[Use of laser impulses in the treatment of melanoblastoma of the skin]. / Lechenie impul'snym lazernym izlucheniem melanoblastom kozhi.

Favourable results of the treatment of skin melanoblastoma by means of pulse laser radiation are reported in 34 patients and of melanoblastoma skin metastasis in 13 patients. The follow-up lasted up to 5 years. There were no cases of local relapse. Metastasis in the regional lymph nodes were found in 5 patients (17%). Before the start of the treatment the latters had not shown any metastasis.

[X-ray study of skin melanoblastomas]. / Rentgenologicheskoe issledovanie melanoblastom kozhi.

The rationale and opportunities of x-ray investigation in skin melanoblastoma are analysed. Roentgenography was employed in 51 patients. In 7 cases the tumor was found to proliferate subcutaneous fat. In 11 cases roentgenological investigation has aided in detailed determination of the form of tumor growth in the obscure clinical picture. The roentgenological investigation made it possible to reliably determine the extent of melanoblastoma spread in underlying tissues, that enabled a more precise planning of the extent of the operation and a more reliable prognostication of the disease.

[Diagnostic value of determining spermidine in the urine of patients with melanoblastoma of the skin]. / Diagnosticheskoe znachenie opredeleniia spermidina v moche u bol'nykh melanoblastomami kozhi

To estimate the diagnostic value of determination of one of polyamines (spermidine) in the urine the authors examined 58 patients with skin melanoblastomas of different localization and 10 healthy persons. It was found that in 16 of 25 patients having only primary tumor, in all 9 patients having primary tumor with metastases in regional lymph nodes, and also in 14 of 20 patients, who after previous therapy developed recurrence or metastases in regional lymph nodes, spermidine excretion exceeded its normal level. In three patients, subjected previously to radical treatment and considered as being clinically recovered, normal spermidine level was excreted. The data obtained enabled the authors to use this test as an adjuvant criterion in examination and treatment of such patients.

[Determination of the histostructure of cutaneous melanoblastomas by cytologic study of smears]. / Opredelenie gistostruktury melanoblastom kozhi pri tsitologicheskom issledovanii mazkov

The work was undertaken to reveal the opportunities of cytological investigations of smears for recognition of the skin melanoblastoma histostructure. Three variants of smear cytograms corresponding to histological types of melanoblastomas were differentiated: epithelioid-cellular, spindle-cell and mixed. In 167 patients press-smears from the tumor surface were studied cytologically with subsequent pathomorphological assay of radically removed neoplasms. Skin melanoblastomas were revealed in all these patients, an epithelioid-cell type - in 119, mixed - in 37, spindle-cell - in 11.

[Humoral antitumor cytotoxins in patients with melanoma of the skin]. / Gumoral'nye protivoopukholevye tsitotoksiny u bol'nykh melanoblastomoi kozhi

The level of humoral antitumor cytotoxins in sera of malignant melanoma patients has been studied by means of a cytotoxic test in vitro. The authors have shown a cytotoxic effect of sera of most patients on autochthonous tumor cells of melanoma. Hela cells were used as a control cell line. There was no cytotoxic effect of sera (of both melanoma patients and healthy donors) on Hela cells. The patients' sera cross-reacted in allogenic combinations of melanoma target cells and sera. Humoral cytotoxins against melanoma tumor cells have also been found tin sera of healthy donors.