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Fast-food workers in Iraq face significant health risks due to exposure to heavy metals from fumes and dust during cooking activities. Heavy metals, such as lead (Pb), cadmium (Cd), and nickel (Ni), are toxic to cells even at low concentrations and can cause health risks, including atherosclerosis, due to oxidative stress and reduced antioxidant activity. To the best of our knowledge, this is the first study assess the levels of heavy metals in fast-food workers and investigate their potential link to atherosclerosis development by monitoring the levels of copper (Cu), zinc (Zn), magnesium (Mg), manganese (Mn), and iron (Fe). A total of 120 male participants aged between 20 and 40 years were included in the study, with 40 fast-food workers, 40 patients with atherosclerosis, and 40 healthy individuals evaluated. The levels of Pb, Cd, Ni, Cu, Zn, Mg, Mn, and Fe in all blood samples were determined using atomic absorption spectrometry. Results showed that the fast-food worker group had significantly higher levels of Pb, Cd, Cu, and Fe compared to the healthy control group, with increases of 57%, 75%, 30%, and 55%, respectively. Conversely, their levels of Zn and Mg were significantly lower, decreasing by 15% and 16%, respectively. On the other hand, the atherosclerosis patients' group had significantly higher levels of Pb, Cd, Cu, and Fe, with increases of 47%, 74%, 34%, and 28%, respectively, as well as significantly lower levels of Zn and Mg, decreasing by 17% and 21%, respectively, compared to the control group. These findings suggest that fast-food workers are at risk of developing atherosclerosis due to exposure to high levels of heavy metals and imbalances in essential trace elements. The results showed a significant increase in the levels of Pb and Cd in the sera of these workers, which was expected because of the long duration and high intensity of exposure to toxic heavy metals. This is a serious indicator that must be considered, as it has been previously established that increased levels of Pb and Cd in the body are linked to the risk of atherosclerosis. Additionally, an association between Pb and Cd levels and an imbalance in trace element levels (Cu, Zn, Mg, and Fe) were observed. The Implementation of stricter regulations and guidelines for maintaining cleanliness and safety in fast-food restaurants may be crucial for protecting workers and preventing long-term health complications.
RESUMO
INTRODUCTION: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease that destroys joints. The concentrations of elements (Zn, Cu, Mg, Mn, Fe, Ni, Cr, K, Na, Ca, Pb, and Cd), as well as antioxidant glutathione GSH and lipid peroxidation marker malondialdehyde MDA, will be determined in this study. METHOD: The study involves 120 female RA patients and 60 healthy females in the control group, all of whom are between the ages of 20 and 60. Patients having diabetes, hypertension, hyperthyroidism, or psoriasis, in addition to RA, were excluded. RESULTS: When RA patients were compared to healthy individuals, the levels of Cu, Ni, Na, Pb, and Cd were significantly higher (p < 0.01), whereas the levels of Zn, Mg, Mn, Cr, Ca, K, and Fe were significantly lower (p < 0.01). The Cu/Zn (2.21 and 1.16) and Na/k (38.67 and 34.87) ratios were also found to be significantly higher in RA patients compared to controls. Furthermore, the data indicated that GSH concentrations in RA patients were significantly lower (p < 0.01) than those in controls (655.90 and 1345.17 mol/l, respectively). MDA levels in RA patients were significantly higher (p < 0.01) than those in controls (2.739 and 1.673 mol/l, respectively). CONCLUSIONS: The data indicate that Cu/Zn and Na/k ratios can be of great value in the diagnosis and evaluation of RA patients. On this basis, we conclude that these elements can be relied upon to provide indications of RA risk and the measurement of oxidative stress can serve as a biomarker to monitor disease activity and severity in RA patients. Key Points ⢠Trace elements may be of value and may have an expected significance in the early diagnosis, prognosis, and treatment evaluation of rheumatoid arthritis. ⢠The distortion in the levels of trace elements may reflect their possible role in the pathogenesis of rheumatoid arthritis. ⢠Oxidative stress can act as a biomarker to monitor disease activity and severity in patients with rheumatoid arthritis. ⢠The trace elements can contribute to the manifestation of inflammatory diseases due to their role in the synthesis of some antioxidants or due to their effect on the immune system.
