[Relationship of the course of nephrotuberculosis in patients to various combinations of genetic markers].

To examine the body's responsiveness in different forms of nepthrotuberculosis, 237 patients underwent comprehensive clinical laboratory studies. To reveal various combinations of genetic markers, the authors determine the phenotypes of haptoglobin, the activity of red blood cell glucose-6-phosphate dehydrogenase, the type of inactivation of isonicotinic acid hydrazide. According to the combinations of a complex of these genetic markers, the authors identified 4 combinations: poor, good, relatively poor, and relatively good. The studies indicated the high incidence of common forms of nephrotuberculosis in subjects with poor and relatively poor combinations of genetic markers. The determination of various chronic renal failure-associated combinations of genetic markers may be used to identify risk groups for this disease.

[Organization of early detection of nephrotuberculosis in risk groups].

The present capacities of early detection of nephrotuberculosis in risk groups are considered in detailed. For this, a total of 1150 patients, including 650 from general health care facilities and 500 from tuberculosis dispensaries, were examined. Comprehensive examination patients from risk groups revealed nephrotuberculosis in 135 (11.7%) patients. The most patients with nephrotuberculosis were identified in the tuberculosis dispensaries (60.7%) whereas these amounted to 39.3% in the general health care facilities. The data of medical history, renal ultrasonography, and urinalysis for Mycobacterium tuberculosis play an important role in the early detection of nephrotuberculosis. The leading techniques in detecting patients with nephrotuberculosis in the risk groups are currently X-ray and ultrasonographic studies that identify 60.5 and 55.7% patients, respectively. The developed clinical, laboratory, and ultrasonographic studies in the tuberculosis dispensaries and general health care facilities considerably enhance the diagnostic capacities of detecting nephrotuberculosis.

[Genetic variants of haptoglobin in patients with nephrotuberculosis]. / Geneticheskie varianty gaptoglobina u bol'nykh nefrotuberkulezom.

Clinical, X-ray, ultrasound, and laboratory studies were made in 152 patients with nephrotic tuberculosis. Haptoglobin phenotypes were defined in the examinees. Nephorotic tuberculosis was found to occur in patients with haptoglobin 2-2 most commonly. There was a relationship between the carriage of a genetically determined haptoglobin phenotype and a difference in the clinical manifestations of hephrotic tuberculosis. The patients with haptoglobin 2-2 were seen to have more severe hephrotic tuberculosis.

[Differential x-ray and ultrasound diagnosis in cavernous renal tuberculosis]. / Differentsial'naia rentgenologicheskaia i ul'trazvukovaia diagnostika kavernoznogo tuberkuleza pochek.

It is virtually very difficult to make a differential diagnosis of cavernous nephrotuberculosis and caliceopyeloectasia (CPE), as well as a combination of caverns and CPE at primary renal ultrasound scanning. Therefore, a complex of diagnostic methods for nephrotuberculosis should include drug echography with a diuretic. Comparing X-ray findings, ultrasound and drug echography with a diuretic allows one to differentiate cavernous nephrotuberculosis from CPE and their combinations with confidence.