An easy-to-use function to assess deep space radiation in human brains.

Health risks from radiation exposure in space are an important factor for astronauts' safety as they venture on long-duration missions to the Moon or Mars. It is important to assess the radiation level inside the human brain to evaluate the possible hazardous effects on the central nervous system especially during solar energetic particle (SEP) events. We use a realistic model of the head/brain structure and calculate the radiation deposit therein by realistic SEP events, also under various shielding scenarios. We then determine the relation between the radiation dose deposited in different parts of the brain and the properties of the SEP events and obtain some simple and ready-to-use functions which can be used to quickly and reliably forecast the event dose in the brain. Such a novel tool can be used from fast nowcasting of the consequences of SEP events to optimization of shielding systems and other mitigation strategies of astronauts in space.

Calculation of dose distribution in a realistic brain structure and the indication of space radiation influence on human brains.

One of the most important steps in the near-future space age will be a crew mission returning to the Moon and even a manned mission to Mars. Unfortunately, such a mission will expose astronauts to unavoidable cosmic radiation in deep space and on the Martian or lunar surface. Thus, a better understanding of the radiation environment for such a mission and the consequent biological impacts on humans, in particular the human brains, is critical. The need for this better understanding is strongly suggested by investigations on animal models and on human patients who were undergoing irradiation for cancer therapy in the head. These have revealed unexpected alterations in the central nervous system behavior and sensitivity of mature neurons in the brain to charged particles. However, such experiments shall not be carried out realistically in space using humans. Therefore, to investigate the impact of cosmic radiation on human brains and the potential influence on the brain functions, we model and study the cosmic particle-induced radiation dose in a realistic head structure. Specifically speaking, 134 slices of computed tomography (CT) images of an actual human head have been used as a 3D phantom in Geant4 (GEometry ANd Tracking), which is a Monte Carlo tool for simulating energetic particles impinging into different parts of the brain and deliver radiation dose therein. As a first step, we compare the influence of different brain structures (e.g., with or without bones, with or without soft tissues) to the resulting dose therein to demonstrate the necessity of using a realistic brain structure for our investigation. Afterward, we calculate energy-dependent functions of dose distribution, for the most important (some of the most abundant and most biologically-relevant) particle types encountered during a deep space mission inside a spacecraft or habitat such as protons, helium ions, neutrons and some major heavier ions like carbon, nitrogen, and iron particles. Furthermore, two different scenarios have been modeled as a comparison: a human head without shielding protection and a human head with an aluminum shielding shell around (of varying thickness). These functions can then be used to fold with energetic cosmic-ray particle spectra of the ambient environment for obtaining the dose rate distribution at different lobes of the human brain. Our calculation of these functions can serve as a ready tool and a baseline for further evaluations of the radiation in the brain encountered during a space mission with different radiation fields, such as on the surface of the Moon or Mars.