[Comparative evaluation of the hypoglycemic activity of the vegetal complex of Phaseolus vulgaris and chlorpropamide in experimental diabetes]. / Sravnitel'naia otsenka gipoglikemicheskoi aktivnosti rastitel'nogo kompleksa iz fasoli obyknovennoi i khlorpropamida pri éksperimental'nom diabete.

Experiments on rabbits with alloxan diabetes showed that the plant complex (PC) reduced the level of glycemia after single administration for 6-8 h by 27-32%. A similar effect was demonstrated with chlorpropamide. However the PC produced a longer hypoglycemic effect. In course treatment the PC returned the blood level of glucose (5.14 +/- 0.62 mmol/l) to normal on the 11th day whereas with chlorpropamide this indicator was almost normal (6.6 +/- 1.1 mmol/l) on the 15th day only. A rapid decrease in the blood glucose concentration caused by the PC was observed in AIS induced hyperglycemia. The PC demonstrated its sugar reducing action by extrapancreatic means.

Biopharmaceutical study of insulin suppositories.

The possibility of insulin administration in suppository dosage form was studied, using different carriers. Highly significantly insulin absorption from the rabbit rectum was obtained by inserting insulin suppositories containing Brij 58 as absorption-promoting surfactant.

[Hypoglycemic activity of aromatic sulfohydrazides and their derivatives]. / Gipoglikemicheskaia aktivnost' aromaticheskikh sul'fogidrazidov i ikh proizvodnykh.

Tests on rabbits revealed the aromatic sulfohydrazides and their derivatives to display hypoglycemic action. A number of compounds superior to butamide by their sugar-lowering action and of low toxicity were discovered. The relationship between the chemical structure of the study substances and their hypoglycemic action is discussed.