RESUMO
Sleep duration is a substantial risk factor for several cardiovascular diseases, including atrial fibrillation (AF). Despite much research, the precise nature of the relationship between the amount of sleep and AF remains unclear. This narrative review explores the relationship between AF and sleep duration, looking at genetic, mechanistic, and epidemiological data to explain this association. A U-shaped association (nonlinear relationship or curvilinear association) between sleep duration and AF has been seen, where longer and shorter sleep duration, more or less than seven to eight hours, have been associated with increased AF risk. Multiple mechanisms such as autonomic dysfunction, inflammation, and structural atrial remodeling have been proposed linking sleep disturbances to AF. Moreover, confounding factors such as individual lifestyle, comorbidities, and sleep quality could affect this association. Additionally, the interpretation of study results is further impacted by methodological limitations, including self-reported sleep duration and observational study designs. It is imperative to comprehend the complex relationship between sleep duration and AF to develop effective preventive and therapeutic methods. The main goals of future research should focus on prospective cohort studies with objective sleep metrics, exploring the mechanistic pathways, and comprehensive confounder adjustments that link sleep disturbances to AF. In summary, addressing sleep disturbances may represent one of the novel approaches to AF prevention and management, with potential implications for improving cardiovascular health and reducing AF-related morbidity and mortality.
RESUMO
The development of hybrid composite antibacterial agents for wound dressing has garnered significant attention due to their remarkable antibacterial efficacy and their potential to mitigate microbial resistance. In this study, we present an approach to designing and fabricating wound dressing membranes, utilizing molybdenum oxide-polyacrylonitrile (MoO3/PAN) hybrid composites through electrospinning. Subsequently, we enhanced the membrane's effectiveness by introducing silver (Ag@MoO3/PAN) into the matrix via a rapid (within one min) green synthesis method under UV irradiation. Initially, we discuss the morphological characteristics and structural attributes of the resulting membranes. Subsequent investigations explore the antibacterial mechanisms of both MoO3 and Ag+, revealing that the incorporation of silver substantially enhanced antibacterial activity. Additionally, we elucidate the surface properties, noting that the introduction of silver increases the surface area of the composite membrane by 25.89% compared with the pristine MoO3/PAN membrane. Furthermore, we observe a 9% reduction in the water contact angle (WCA) for the Ag@MoO3/PAN membrane, indicating improved hydrophilicity. Finally, we analyze the release behavior of the Ag@MoO3/PAN membrane. Our findings demonstrate an initial burst release within the first 7 h, followed by a controlled and sustained release pattern over a period of 7 days.