Castleman Disease Mimicking Pancreatic Neuroendocrine Tumour: Interpretation of Positron Emission Tomography in Pancreatic Incidentaloma.

We report a rare case of an incidental pancreatic lesion that proved to be Castleman disease in a peripancreatic lymph node, which mimicked a high-grade pancreatic neuroendocrine tumour (PNET) based on findings on positron emission tomography (PET). The disease was discovered as an incidental finding on CT imaging of the abdomen and was investigated and managed as PNET. Surgical resection was performed with distal pancreatectomy and splenectomy, however, histology revealed the lesion was a lymph node affected by Castleman disease. Often termed the great mimic, Castleman disease is a rare lymphoproliferative disorder that is often mistaken for other primary lesions of the organ due to its location and should be considered a differential of fluorodeoxyglucose (FDG)-avid PET lesions on imaging.

Metastatic Breast Cancer Presenting as Acute Appendicitis.

Breast cancer is one of the most commonly diagnosed cancers in Australia. With the development in screening, diagnosis, and treatment, people are living longer with metastatic disease of the breast. This malignancy commonly metastasizes to the lung, brain, bone, and liver. However, due to the increased survival of patients living with breast cancer, metastases may present with complications that have not been seen before. We describe a case of a 55-year-old female with a background of metastatic breast cancer to the brain who presented to the emergency department with acute appendicitis. At surgery, a malignant mass was found in the cecum obstructing the appendix, and histopathology revealed metastatic breast cancer.