RESUMO
In 2001, the measles immunization schedule in Saudi Arabia was changed to 2 measles, mumps and rubella vaccine doses at 12 months and at 6 years. In this follow-up study we evaluated the seroresponse to the second measles dose before school entry. We recruited 138 children randomly from primary health care centres in Qassim; 124 children completed the study. Blood samples were collected before and 1 month after giving the second measles dose, before the age of 6 years. There was a statistically significant increase in the geometric mean titre of measles antibody, from 2205 m IU/mL before vaccination to 4723 mlU/mL after (P = 0.0001). The proportion of children with positive ELISA results increased fro++ 94.2% before vaccination to 99.2% after (P = 0.02), while the proportion with protective level (> or = 200 mlU/mL) increased from 97.1% before vaccination to 99.19% after (P = 0.21). The 2-dose measles immunization schedule can produce optimum protection at school entry if high vaccination coverage is guaranteed.
Assuntos
Anticorpos Antivirais/sangue , Imunização Secundária , Vacina contra Sarampo/imunologia , Vírus do Sarampo/imunologia , Sarampo/imunologia , Criança , Pré-Escolar , Feminino , Seguimentos , Humanos , Masculino , Sarampo/sangue , Sarampo/prevenção & controle , Vacina contra Sarampo/administração & dosagem , Arábia Saudita , Estudos SoroepidemiológicosRESUMO
In 2001, the measles immunization schedule in Saudi Arabia was changed to 2 measles, mumps and rubella vaccine doses at 12 months and at 6 years. In this follow-up study we evaluated the seroresponse to the second measles dose before school entry. We recruited 138 children randomly from primary health care centres in Qassinn; 124 children completed the study. Blood samples were collected before and 1 month after giving the second measles dose, before the age of 6 years. There was a statistically significant increase in the geometric mean titre of measles antibody, from 2205 m lU/mL before vaccination to 4723 mlU/mL after [P = 0.0001]. The proportion of children with positive ELISA results increased fro++ 94.2% before vaccination to 99.2% after [P = 0.02], while the proportion with protective level [
Assuntos
Imunização Secundária , Esquemas de Imunização , Instituições Acadêmicas , Ensaio de Imunoadsorção Enzimática , Vacina contra SarampoRESUMO
In 1990, Saudi Arabia began vaccinating all children at school entry against hepatitis B. We evaluated hepatitis B surface antigen (HBsAg) prevalence rate among pregnant Saudi women 12 years later in 5 regions of the country. Using multistage sampling, 2664 pregnant Saudi women were recruited. Blood samples were tested for HBsAg; positive samples were also tested for hepatitis Be antigen (HBeAg). In all 2.44% were positive for HBsAg and 4 (0.15%) were also positive for HBeAg. HBsAg prevalence was highest in Gizan (4.2%) and lowest in Tabuk (1.4%). Positivity for women < or = 20 years of age was 0.5% compared with 2.6% for older women (P = 0.049). The overall HBsAg prevalence rate was lower than previously reported.
Assuntos
Antígenos de Superfície da Hepatite B/sangue , Hepatite B/epidemiologia , Complicações Infecciosas na Gravidez/epidemiologia , Adulto , Distribuição por Idade , Portador Sadio/epidemiologia , Causalidade , Estudos Transversais , Assistência Odontológica/efeitos adversos , Feminino , Necessidades e Demandas de Serviços de Saúde , Hepatite B/sangue , Hepatite B/imunologia , Hepatite B/prevenção & controle , Antígenos E da Hepatite B/sangue , Humanos , Programas de Rastreamento , Vacinação em Massa/organização & administração , Gravidez , Complicações Infecciosas na Gravidez/sangue , Complicações Infecciosas na Gravidez/imunologia , Complicações Infecciosas na Gravidez/prevenção & controle , Avaliação de Programas e Projetos de Saúde , Características de Residência , Arábia Saudita/epidemiologia , Estudos Soroepidemiológicos , Procedimentos Cirúrgicos Operatórios/efeitos adversos , Reação TransfusionalRESUMO
In 1990, Saudi Arabia began vaccinating all children at school entry against hepatitis B. We evaluated hepatitis B surface antigen [HBsAg] prevalence rate among pregnant Saudi women 12 years later in 5 regions of the country. Using multistage sampling, 2664 pregnant Saudi women were recruited. Blood samples were tested for HBsAg; positive samples were also tested for hepatitis Be antigen [HBeAg]. In all 2.44% were positive for HBsAg and 4 [0.15%] were also positive for HBeAg. HBsAg prevalence was highest in Gizan [4.2%] and lowest in Tabuk [1.4%]. Positivity for women < or = 20 years of age was 0.5% compared with 2.6% for older women [P = 0.049]. The overall HBsAg prevalence rate was lower than previously reported
Assuntos
Distribuição por Idade , Transfusão de Sangue , Portador Sadio , Causalidade , Estudos Transversais , Antígenos de Superfície da Hepatite B , Hepatite BRESUMO
We carried out a follow-up study to investigate variation in short-term outcome for preterm infants in 2 hospitals in Buraidah. We compared gestational age, birth weight, head circumference at birth and length of stay. Outcome measures were weight gain/day, feeding pattern on discharge and feeding pattern 1 month after discharge. Mean weight gain was significantly higher in hospital A, 9.6 [+/- 19.7] g/day compared to -1.2 [+/- 29.5] g/day in hospital B [P = 0.049]. The proportion of infants exclusively breastfed 1 month after discharge was 37.5% in hospital B compared to 13.2% in hospital A [P = 0.0224]. There are clear hospital level differences in short-term outcome in the same region, emphasizing the need for continuous follow-up and evaluation of differences in a perinatal audit
