[Effect of combined therapy using complex of natural cytokines and antimicrobial peptides in urogenital infections caused by Chlamydia and Mycoplasma].

AIM: To study efficacy of complex therapy of urogenital infections caused by Chlamydia and Mycoplasma using immunomodulator Superlimph. MATERIALS AND METHODS: Fifty males and thirty six females ages 22 - 47 years old with chronic urogenital infections--cervicitis and vulvovaginitis (females), prostatitis (males)--were studied. PCR and bacteriologic methods were used for diagnostics of mixed infection and microbiota efficiency. Patients were divided on 3 groups according to treatment protocol. Twenty patients (group 1)--standard therapy (josamycin), 48 patients received immunomodulator (suppositorium) before treatment with josamycin (group 2), 18 patients were simultaneously treated with josamycin and immunomodulator (group 3). RESULTS: Combinations of Chlamydia trachomatis, Ureaplasma urealyticum, Gardnerella vaginalis and Mycoplasma genitalium were identified in 30 - 35% of cases before treatment. After treatment with josamycin (group 1) or simultaneous therapy with josamycin and immunomodulator (group 3) considerable suppression of growth and elimination of both main pathogens and members of microbiota. Use of immunomodulator (group 2) in some cases resulted elimination of main pathogens and associated opportunistic microflora. CONCLUSION: Microbiological monitoring in 97% cases demonstrated therapeutic effect of immunomodulator Superlymph on urogenital infections associated with Chlamydia and Mycoplasma and disbiotic microbiota of urogenital tract.

[Endocrine disturbances in circumscribed scleroderma].

AIM: To evaluate prevalence of endocrine pathology in patients with circumscribed scleroderma (CS), baseline immunopathological alterations in CS patients. MATERIAL AND METHODS: Circulating immune complexes were studied by the Digeon method in a total of 70 CS patients (female 52, 74.3%; male 18, 25.7%; age 16 to 70 years). RESULTS: Circulating immune complexes assay by Digeon detected evident immune imbalance characteristic for metabolic disturbances of the connective tissue and affection of the endocrine system. CONCLUSION: CS patients need a combined examination including endocrinological and immunological tests.

[Lupus erythematosus: effects of different therapeutic methods on intranuclear characteristics of lymphoid cells]. / Vliianie razlichnykh metodov lecheniia krasnoi volchanki na vnutriiadernye kharakteristiki limfoidnykh kletok.

In lymphocytes of peripheral blood from 46 patients with various forms of lupus erythematosus measurements were made of histone fractions and DNA. It is proved that intranuclear characteristics of lymphoid cells can be used in the choice of treatment and assessment of its efficacy. Lupus erythematosus treatment with glucocorticoids (diprospan, diprospan + celeston) is effective in correction of intranuclear lymphocyte changes in this disease.

[An analysis of the lymphoid cell histones in patients with different forms of lupus erythematosus]. / Analiz gistonov limfoidnykh kletok u bol'nykh s razlichnymi formami krasnoi volchanki.

The study was made of lisine- and arginine-rich histone fractions and DNA in lymphocytes of peripheral blood in patients with lupus erythematosus. The findings showed intranuclear changes of immunocompetent cells in various forms of the disease. The above parameters may be used in the diagnosis, evaluation of treatment efficacy, prognosis.

[The use of a pulsed magnetic field in the treatment of lupus erythematosus]. / Primenenie impul'snogo magnitnogo polia pri lechenii krasnoi volchanki.

The authors review literature data on application of impulsed magnetic field (IMF) in clinical practice. IMF introduction in LE treatment is thought beneficial because IMF antiinflammatory, analgetic effects, positive action on microcirculation, immunological reactivity, the ability to upgrade the effect of combined therapy. The trends observed in the clinical and laboratory indices allowed the authors to recommend IMF for wide application in LE.

[Generalized herpes in a pregnant patient]. / Generalizovannyi gerpes u beremennoi.

A clinical description of generalized herpes in a pregnant patient is presented. Virological and serological studies have confirmed the diagnosis.

[Dipromonium in the treatment of scleroderma patients]. / Dipromonii v lechenii bol'nykh sklerodermiei.

Basing on the literature data on dipromonium biochemical and pharmacologic characteristics and on her own experience, the author has developed the treatment schemes with due consideration for scleroderma severity. The treatment has been associated with a reduction of glycosaminoglycan excretion with the urine, this correlating with the clinical improvement resultant from dipromonium therapy.

[Erythema nodosum in patients with hypertrophy of the nasopharyngeal tonsil]. / Uzlovataia éritema u bol'nykh s gipertrofiei nosoglotochnoi mindaliny.

The author analyzes the clinical observations of erythema nodosum in patients with hypertrophic nasopharyngeal tonsils. Basing on the literature data and her own observations, she suggests a relationship between adenoid growth and nodular eruption.

[The clinical efficacy and outlook for the use of new drugs for metabolic therapy in dermatology]. / Klinicheskaia éffektivnost' i perspektivy primeneniia nekotorykh novykh sredstv metabolicheskoi terapii v dermatologii.

Based on the literature data and their own findings, the authors give grounds for the use of phosphaden, riboxin, and dipromonium in psoriasis, eczema, and atrophic lichen. Prospects in the application of vitamin synthetic analogues and of coenzymic preparations are shown.

[The different clinical variants of scleroderma in diabetics]. / Razlichnye klinicheskie varianty skelrodermii u bol'nykh sakharnym diabetom.

The course of scleroderma is compared in patients with and without diabetes mellitus. In combined pathology, bullous foci of injury and trophic abnormalities occur more frequently. All the patients were diagnosed to have abnormalities on the part of connective tissue metabolism.

[The combined treatment with aurobin and dipromonium of focal scleroderma]. / Kompleksnoe lechenie aurobinom i dipromoniem ochagovoi sklerodermii.

Aurobin ointment has been used for the treatment of scleroderma foci localized on the external genitals. Combined therapy including aurobin has been fairly effective. Clinical improvement has been paralleled by a reduction of the blood serum glycosamino-glycane level.