Assuntos
Cirrose Hepática/fisiopatologia , Fígado/irrigação sanguínea , Sistema Renina-Angiotensina , Adulto , Ascite/fisiopatologia , Varizes Esofágicas e Gástricas/fisiopatologia , Feminino , Hemorragia Gastrointestinal/fisiopatologia , Humanos , Icterícia/fisiopatologia , Masculino , Microcirculação/fisiopatologia , Pessoa de Meia-IdadeRESUMO
In 30 male rats of Wistar strain (20 more rats served as controls) thickness of the internal elastic membrane, that of the media, cross section area of the media and that of the lumen were define 3, 4, 5 and 6 months after the experiment was started. The initial changes in the hepatic artery structure are noted on the 4th month, however, differences in the parameters are not yet statistically significant. On the 5th month certain signs of hypertrophy in the smooth muscle cells of the media are clearly seen, as well as an increasing thickness of the internal elastic membrane and that of the tunica media. Simultaneously, the index of labelling the myocyte nuclei reaches its maximum. The increasing thickness of the arterial wall causes certain decrease in the lumen cross section area. The changes of all the parameters are statistically significant. In 6 months after the beginning of the experiment, a pronounced hyperelastosis develops in the wall of the hepatic artery; a part of the smooth muscle cells in the tunica media undergoes atrophy. The area of the vascular lumen decreases by 16%, comparing to the age control. The experimental data confirm certain clinical observations and reveal some features in the mechanism of pathological changes occurring in the hepatic artery wall at cirrhosis.
Assuntos
Artéria Hepática/patologia , Cirrose Hepática Experimental/patologia , Animais , Autorradiografia , DNA/biossíntese , Artéria Hepática/ultraestrutura , Cirrose Hepática Experimental/metabolismo , Masculino , Músculo Liso Vascular/metabolismo , Ratos , Ratos Endogâmicos , Timidina/metabolismoAssuntos
Hipertensão Portal/cirurgia , Cirrose Hepática/cirurgia , Derivação Portossistêmica Cirúrgica , Derivação Esplenorrenal Cirúrgica , Ducto Torácico/cirurgia , Adolescente , Adulto , Idoso , Criança , Drenagem , Feminino , Humanos , Hipertensão Portal/complicações , Ligadura , Cirrose Hepática/complicações , Masculino , Pessoa de Meia-Idade , Esplenectomia , Estômago/irrigação sanguíneaRESUMO
On the basis of an analysis of rentgeno-morphological investigations of the thoracic lymphatic duct (TLD) in 115 patients with complications of hepatocirrhosis and 50 postmortem observations the authors make a conclusion that one of the main factors of the development of insufficiency of TLD in hepatocirrhosis is an excess of lymph resulting in congestion in the duct. It may be considered as a cause for drainage of the TLD in patients with hepatocirrhosis.
