RESUMO
The aim was to investigate compare genotype and allele frequencies of the GPX1 gene Pro198Leu polymorphism in 736 Russian athletes and 564 non-athletic controls. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). Also, we investigated whether glutathione had antioxidant effects in runners. Runners of the experimental group 1 (16 persons) unlike the group 2 (16 persons) had been administered 600 mg of glutathione sodium intramuscularly after trainings daily, during 14 days. The best response to glutathione was presented by the GPX1 Pro allele.
Assuntos
Antioxidantes/administração & dosagem , Atletas , Glutationa Peroxidase/genética , Glutationa/administração & dosagem , Consumo de Oxigênio/genética , Adulto , Alelos , Estudos de Casos e Controles , Feminino , Expressão Gênica , Frequência do Gene , Genótipo , Heterozigoto , Homozigoto , Humanos , Injeções Intramusculares , Leucina/genética , Masculino , Resistência Física/fisiologia , Polimorfismo de Nucleotídeo Único , Prolina/genética , Glutationa Peroxidase GPX1RESUMO
The aim of the was to investigate the interrelation between MTHFR gene C677T polymorphism and morphometric echocardiography and physiologic parameters in male ski racers (n = 23). Genotyping was performed by RFLP. Echocardiography was performed by ultrasound scanner Nemio MX (Toshiba, Japan). We found that the MTHFR C677 allele was associated with low myocardial growth and high physical performance of athletes.
