RESUMO
BACKGROUND: Persistent infection with high-risk (HR) HPV genotypes has been associated with cervical cancer, the third cancer affecting women in Oman with a crude incidence rate of 4.7 and mortality rate of 2.5 respectively. Other types of lower-risk (LR) HPV are associated with warts in both genders worldwide. OBJECTIVES: To assess the prevalence and genotype distribution of HPV and the risk factors among women with normal and abnormal cytology. METHODS: A cross sectional study conducted between September 2014 and April 2015. 258 cervical samples were obtained from women aged 18-68 years attending the Gynaecology Out-patient Clinic. HPV genotyping was performed using a multiplex real time-polymerase chain reaction (RT-PCR) assay. RESULTS: 22 different HPV genotypes were detected in 46 women (17.8%) and included 15 HR and 7 LR genotypes. Human immunodeficiency virus (HIV) patients (P = 0.052) and oral contraceptives users (P = 0.016) showed significant association with HPV infection. CONCLUSION: The most frequently observed HPV types were HR HPV 82 and LR HPV 54. These findings show that the predominant HPV genotypes in Oman are different from those seen in worldwide studies. This finding is important to determine the potential impact of preventive measures especially new vaccines to reduce the burden of cervical cancer.
Assuntos
Papillomaviridae/genética , Infecções por Papillomavirus/epidemiologia , Adolescente , Adulto , Idoso , Coinfecção , Estudos Transversais , Feminino , Genótipo , Técnicas de Genotipagem , Infecções por HIV/complicações , Humanos , Pessoa de Meia-Idade , Omã/epidemiologia , Papillomaviridae/isolamento & purificação , Infecções por Papillomavirus/microbiologia , Prevalência , Reação em Cadeia da Polimerase em Tempo Real , Fatores de Risco , Adulto JovemRESUMO
Human parvovirus B19 (HPV B19) infections are usually asymptomatic or benign and self-limiting. In immunocompromised patients and patients with chronic hemolytic anemia, it can lead to transient red cell aplasia. Few reports in the literature have implicated HPV B19 as the possible cause of acute hepatitis and severe aplastic anemia in immunocompetent patients. Here, the authors report a previously healthy 6-year-old girl with acute hepatitis and severe aplastic anemia associated with HPV B19 infection diagnosed by serology (ELISA). Other common causes of these manifestations were ruled out. The clinical manifestations subsequently improved significantly with the use of immunosuppressive therapy confirming an autoimmune mechanism.
